Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease

Joseline Ojaimi; Colin L. Masters; Catriona McLean; Ken Opeskin; Penny McKelvie; Edward Byrne

doi:10.1002/1531-8249(199910)46:4<656::AID-ANA16>3.0.CO;2-Q

Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease

Joseline Ojaimi, Colin L. Masters, Catriona McLean, Ken Opeskin, Penny McKelvie, Edward Byrne

Research output: Contribution to journal › Article › Research › peer-review

54 Citations (Scopus)

Abstract

This study aims to investigate the cellular distribution of human cytochrome c oxidase (COX) subunit II (CII) and COX subunit IV (CIV) in Alzheimer's disease relative to control brains. The levels of CIV and CII proteins in the cerebellar Purkinje cells were reduced in age-matched controls relative to young controls and in the Alzheimer's disease group relative to both age-matched and young controls. Results suggest that these age-associated changes are more marked in Alzheimer's disease.

Original language	English
Pages (from-to)	656-660
Number of pages	5
Journal	Annals of Neurology
Volume	46
Issue number	4
DOIs	https://doi.org/10.1002/1531-8249(199910)46:4<656::AID-ANA16>3.0.CO;2-Q
Publication status	Published - 1999
Externally published	Yes

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SDG 3 Good Health and Well-being

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10.1002/1531-8249(199910)46:4<656::AID-ANA16>3.0.CO;2-Q

Cite this

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abstract = "This study aims to investigate the cellular distribution of human cytochrome c oxidase (COX) subunit II (CII) and COX subunit IV (CIV) in Alzheimer's disease relative to control brains. The levels of CIV and CII proteins in the cerebellar Purkinje cells were reduced in age-matched controls relative to young controls and in the Alzheimer's disease group relative to both age-matched and young controls. Results suggest that these age-associated changes are more marked in Alzheimer's disease.",

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T1 - Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease

AU - Ojaimi, Joseline

AU - Masters, Colin L.

AU - McLean, Catriona

AU - Opeskin, Ken

AU - McKelvie, Penny

AU - Byrne, Edward

PY - 1999

Y1 - 1999

N2 - This study aims to investigate the cellular distribution of human cytochrome c oxidase (COX) subunit II (CII) and COX subunit IV (CIV) in Alzheimer's disease relative to control brains. The levels of CIV and CII proteins in the cerebellar Purkinje cells were reduced in age-matched controls relative to young controls and in the Alzheimer's disease group relative to both age-matched and young controls. Results suggest that these age-associated changes are more marked in Alzheimer's disease.

AB - This study aims to investigate the cellular distribution of human cytochrome c oxidase (COX) subunit II (CII) and COX subunit IV (CIV) in Alzheimer's disease relative to control brains. The levels of CIV and CII proteins in the cerebellar Purkinje cells were reduced in age-matched controls relative to young controls and in the Alzheimer's disease group relative to both age-matched and young controls. Results suggest that these age-associated changes are more marked in Alzheimer's disease.

UR - https://www.scopus.com/pages/publications/0032850682

U2 - 10.1002/1531-8249(199910)46:4<656::AID-ANA16>3.0.CO;2-Q

DO - 10.1002/1531-8249(199910)46:4<656::AID-ANA16>3.0.CO;2-Q

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AN - SCOPUS:0032850682

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JO - Annals of Neurology

JF - Annals of Neurology

IS - 4

ER -

Irregular distribution of cytochrome c oxidase protein subunits in aging and Alzheimer's disease

Abstract

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