IRF5-mediated immune responses and its implications in immunological disorders

Ashwinder Kaur, Learn Han Lee, Sek Chuen Chow, Chee Mun Fang

    Research output: Contribution to journalReview ArticleResearchpeer-review

    15 Citations (Scopus)

    Abstract

    Transcription factors are gene regulators that activate or repress target genes. One family of the transcription factors that have been extensively studied for their crucial role in regulating gene network in the immune system is the interferon regulatory factors (IRFs). IRFs possess a novel turn-helix turn motif that recognizes a specific DNA consensus found in the promoters of many genes that are involved in immune responses. IRF5, a member of IRFs has recently gained much attention for its role in regulating inflammatory responses and autoimmune diseases. Here, we discuss the role of IRF5 in regulating immune cells functions and how the dysregulation of IRF5 contributes to the pathogenesis of immune disorders. We also review the latest findings of potential IRF5 inhibitors that modulate IRF5 activity in the effort of developing therapeutic approaches for treating inflammatory disorders.

    Original languageEnglish
    Pages (from-to)229-248
    Number of pages20
    JournalInternational Reviews of Immunology
    Volume37
    Issue number5
    DOIs
    Publication statusPublished - 20 Nov 2018

    Keywords

    • Autoimmune diseases
    • immune cells
    • inflammatory disorders
    • interferon regulatory factor 5
    • transcription factor

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