IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis

Michael Sze Yuan Low; Erica J. Brodie; Pasquale L. Fedele; Yang Liao; George Grigoriadis; Andreas Strasser; Axel Kallies; Simon N. Willis; Julie Tellier; Wei Shi; Sarah Gabriel; Kristy O'Donnell; Catherine Pitt; Stephen L. Nutt; David Tarlinton

doi:10.1016/j.celrep.2019.10.097

IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis

Michael Sze Yuan Low, Erica J. Brodie, Pasquale L. Fedele, Yang Liao, George Grigoriadis, Andreas Strasser, Axel Kallies, Simon N. Willis, Julie Tellier, Wei Shi, Sarah Gabriel, Kristy O'Donnell, Catherine Pitt, Stephen L. Nutt, David Tarlinton

Research output: Contribution to journal › Article › Research › peer-review

48 Citations (Scopus)

Abstract

Plasma cells can provide lifelong immunity by the continued production of high-affinity, antigen-specific antibody. Low et al. reveal that the transcription factor IRF4 acts within established plasma cells to prevent apoptosis and maintain cellular identity and mitochondrial homeostasis.

Original language	English
Pages (from-to)	2634-2645.e5
Number of pages	18
Journal	Cell Reports
Volume	29
Issue number	9
DOIs	https://doi.org/10.1016/j.celrep.2019.10.097
Publication status	Published - 26 Nov 2019

Keywords

antibody
BLIMP1
cell survival
gene expression
humoral immunity
metabolism
myeloma

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10.1016/j.celrep.2019.10.097Licence: CC BY-NC-ND

290701293-oaFinal published version, 2.43 MBLicence: CC BY-NC-ND

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Low, M. S. Y., Brodie, E. J., Fedele, P. L., Liao, Y., Grigoriadis, G., Strasser, A., Kallies, A., Willis, S. N., Tellier, J., Shi, W., Gabriel, S., O'Donnell, K., Pitt, C., Nutt, S. L., & Tarlinton, D. (2019). IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis. Cell Reports, 29(9), 2634-2645.e5. https://doi.org/10.1016/j.celrep.2019.10.097

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abstract = "Plasma cells can provide lifelong immunity by the continued production of high-affinity, antigen-specific antibody. Low et al. reveal that the transcription factor IRF4 acts within established plasma cells to prevent apoptosis and maintain cellular identity and mitochondrial homeostasis.",

keywords = "antibody, BLIMP1, cell survival, gene expression, humoral immunity, metabolism, myeloma",

author = "Low, {Michael Sze Yuan} and Brodie, {Erica J.} and Fedele, {Pasquale L.} and Yang Liao and George Grigoriadis and Andreas Strasser and Axel Kallies and Willis, {Simon N.} and Julie Tellier and Wei Shi and Sarah Gabriel and Kristy O'Donnell and Catherine Pitt and Nutt, {Stephen L.} and David Tarlinton",

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doi = "10.1016/j.celrep.2019.10.097",

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Low, MSY , Brodie, EJ, Fedele, PL, Liao, Y, Grigoriadis, G, Strasser, A, Kallies, A, Willis, SN, Tellier, J, Shi, W, Gabriel, S, O'Donnell, K, Pitt, C, Nutt, SL & Tarlinton, D 2019, 'IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis', Cell Reports, vol. 29, no. 9, pp. 2634-2645.e5. https://doi.org/10.1016/j.celrep.2019.10.097

TY - JOUR

T1 - IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis

AU - Low, Michael Sze Yuan

AU - Brodie, Erica J.

AU - Fedele, Pasquale L.

AU - Liao, Yang

AU - Grigoriadis, George

AU - Strasser, Andreas

AU - Kallies, Axel

AU - Willis, Simon N.

AU - Tellier, Julie

AU - Shi, Wei

AU - Gabriel, Sarah

AU - O'Donnell, Kristy

AU - Pitt, Catherine

AU - Nutt, Stephen L.

AU - Tarlinton, David

PY - 2019/11/26

Y1 - 2019/11/26

N2 - Plasma cells can provide lifelong immunity by the continued production of high-affinity, antigen-specific antibody. Low et al. reveal that the transcription factor IRF4 acts within established plasma cells to prevent apoptosis and maintain cellular identity and mitochondrial homeostasis.

AB - Plasma cells can provide lifelong immunity by the continued production of high-affinity, antigen-specific antibody. Low et al. reveal that the transcription factor IRF4 acts within established plasma cells to prevent apoptosis and maintain cellular identity and mitochondrial homeostasis.

KW - antibody

KW - BLIMP1

KW - cell survival

KW - gene expression

KW - humoral immunity

KW - metabolism

KW - myeloma

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U2 - 10.1016/j.celrep.2019.10.097

DO - 10.1016/j.celrep.2019.10.097

M3 - Article

AN - SCOPUS:85075473460

SN - 2211-1247

VL - 29

SP - 2634-2645.e5

JO - Cell Reports

JF - Cell Reports

IS - 9

ER -

IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis

Abstract

Keywords

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