IRF4 Activity Is Required in Established Plasma Cells to Regulate Gene Transcription and Mitochondrial Homeostasis

Michael Sze Yuan Low, Erica J. Brodie, Pasquale L. Fedele, Yang Liao, George Grigoriadis, Andreas Strasser, Axel Kallies, Simon N. Willis, Julie Tellier, Wei Shi, Sarah Gabriel, Kristy O'Donnell, Catherine Pitt, Stephen L. Nutt, David Tarlinton

Research output: Contribution to journalArticleResearchpeer-review

16 Citations (Scopus)

Abstract

Plasma cells can provide lifelong immunity by the continued production of high-affinity, antigen-specific antibody. Low et al. reveal that the transcription factor IRF4 acts within established plasma cells to prevent apoptosis and maintain cellular identity and mitochondrial homeostasis.

Original languageEnglish
Pages (from-to)2634-2645.e5
Number of pages18
JournalCell Reports
Volume29
Issue number9
DOIs
Publication statusPublished - 26 Nov 2019

Keywords

  • antibody
  • BLIMP1
  • cell survival
  • gene expression
  • humoral immunity
  • metabolism
  • myeloma

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