Ionization constants and ionization profiles

David Thomas Manallack, John E A Comer

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Other


Most drug molecules are ionizable in aqueous solutions. Ionization occurs when the molecules acquire or lose hydrogen ions in response to changes in the pH of the solution. This chapter reviews the theory of solution equilibria, which explains the behavior of ionizable molecules in solution, and describes the structural features of organic molecules that cause them to become ionized. It then discusses the importance of drug ionization, before moving on to consider the measurement of ionization constants, and techniques for predicting them by studying molecular structure.
Original languageEnglish
Title of host publicationReference Module in Chemistry, Molecular Sciences and Chemical Engineering
EditorsJan Reedijk
Place of PublicationNew York NY USA
Pages1 - 41
Number of pages41
ISBN (Print)9780124095472
Publication statusPublished - 2014

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