Ionic liquids provide unique opportunities for oral drug delivery: Structure optimization and in vivo evidence of utility

Hywel David Williams, Yasemin Sahbaz, Leigh Ford, Tri-Hung Nguyen, Peter John Scammells, Christopher John Porter

Research output: Contribution to journalArticleResearchpeer-review

55 Citations (Scopus)

Abstract

Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.
Original languageEnglish
Pages (from-to)1688 - 1690
Number of pages3
JournalChemical Communications
Volume50
Issue number14
DOIs
Publication statusPublished - 2014

Cite this

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abstract = "Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.",
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Ionic liquids provide unique opportunities for oral drug delivery: Structure optimization and in vivo evidence of utility. / Williams, Hywel David; Sahbaz, Yasemin; Ford, Leigh; Nguyen, Tri-Hung; Scammells, Peter John; Porter, Christopher John.

In: Chemical Communications, Vol. 50, No. 14, 2014, p. 1688 - 1690.

Research output: Contribution to journalArticleResearchpeer-review

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T1 - Ionic liquids provide unique opportunities for oral drug delivery: Structure optimization and in vivo evidence of utility

AU - Williams, Hywel David

AU - Sahbaz, Yasemin

AU - Ford, Leigh

AU - Nguyen, Tri-Hung

AU - Scammells, Peter John

AU - Porter, Christopher John

PY - 2014

Y1 - 2014

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AB - Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.

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DO - 10.1039/c3cc48650h

M3 - Article

VL - 50

SP - 1688

EP - 1690

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 14

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