Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 1688 - 1690 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 50 |
| Issue number | 14 |
| DOIs | |
| Publication status | Published - 2014 |
Cite this
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Ionic liquids provide unique opportunities for oral drug delivery: Structure optimization and in vivo evidence of utility. / Williams, Hywel David; Sahbaz, Yasemin; Ford, Leigh; Nguyen, Tri-Hung; Scammells, Peter John; Porter, Christopher John.
In: Chemical Communications, Vol. 50, No. 14, 2014, p. 1688 - 1690.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Ionic liquids provide unique opportunities for oral drug delivery: Structure optimization and in vivo evidence of utility
AU - Williams, Hywel David
AU - Sahbaz, Yasemin
AU - Ford, Leigh
AU - Nguyen, Tri-Hung
AU - Scammells, Peter John
AU - Porter, Christopher John
PY - 2014
Y1 - 2014
N2 - Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.
AB - Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.
UR - http://pubs.rsc.org/en/Content/ArticleLanding/2014/CC/c3cc48650h#!divAbstract
U2 - 10.1039/c3cc48650h
DO - 10.1039/c3cc48650h
M3 - Article
VL - 50
SP - 1688
EP - 1690
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 14
ER -