TY - JOUR
T1 - Ionic liquids provide unique opportunities for oral drug delivery
T2 - Structure optimization and in vivo evidence of utility
AU - Williams, Hywel David
AU - Sahbaz, Yasemin
AU - Ford, Leigh
AU - Nguyen, Tri-Hung
AU - Scammells, Peter John
AU - Porter, Christopher John
PY - 2014
Y1 - 2014
N2 - Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.
AB - Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.
U2 - 10.1039/c3cc48650h
DO - 10.1039/c3cc48650h
M3 - Article
VL - 50
SP - 1688
EP - 1690
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 14
ER -