Ionic liquids provide unique opportunities for oral drug delivery: Structure optimization and in vivo evidence of utility

Hywel David Williams, Yasemin Sahbaz, Leigh Ford, Tri-Hung Nguyen, Peter John Scammells, Christopher John Porter

Research output: Contribution to journalArticleResearchpeer-review

68 Citations (Scopus)

Abstract

Ionic liquids (ILs) have been exploited to improve the absorption of poorly water-soluble drugs. Custom-made ILs solubilized very high quantities of the poorly water-soluble drugs, danazol and itraconazole, and maintained drug solubilization under simulated gastro-intestinal conditions. A danazol-containing self-emulsifying IL formulation gave rise to 4.3-fold higher exposure than the crystalline drug and prolonged exposure compared with a lipid formulation.
Original languageEnglish
Pages (from-to)1688 - 1690
Number of pages3
JournalChemical Communications
Volume50
Issue number14
DOIs
Publication statusPublished - 2014

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