Ionic characteristics in cardiac alternans suppression using T ± ε feedback control

Shiuan Ni Liang, Duy Manh Le, Pik Yin Lai, C. K. Chan

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    Using the Luo-Rudy I model, the recently proposed T ± ϵ feedback control for suppressing cardiac alternans is investigated. It is shown that cardiac alternans, induced by fast pacing (of period T), can be dramatically reduced by small changes of fixed magnitude (ϵ) under feedback control when ϵ exceeds a critical threshold. Detail information on various ionic currents and cytosolic calcium concentration ϵ([Ca]i) are examined when the cardiac cell is under control. In particular, the alternans in ionic currents and [Ca]i are also reduced under the control. Furthermore, when ϵ exceeds the threshold value, the average [Ca]i level is significantly higher when the alternans is under control, suggesting a possible physiological improvement of cardiac contractions.

    Original languageEnglish
    Article number48001
    Number of pages6
    Issue number4
    Publication statusPublished - Aug 2016

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