Ion channels and the signal transduction pathways in the regulation of growth hormone secretion

Chen Chen, Jean Didier Vincent, Iain J. Clarke

Research output: Contribution to journalShort SurveyOtherpeer-review

79 Citations (Scopus)

Abstract

The secretion of GH from pituitary somatotrophs is mainly regulated by alterations in the levels of intracellular free Ca2+ concentrations ([Ca2+]i) that depend on the influx of Ca2+ through voltage-gated Ca2+ channels in the cell membrane. Hypothalamic stimulatory and inhibitory factors bind to specific receptors on the cell membrane to regulate membrane potential and activate second-messenger systems. The receptors are G-protein coupled, and activated G proteins directly influence membrane ion channels to regulate Ca2+ influx. The function of cAMP-dependent protein kinase A is also modulated by receptor-coupled G proteins leading to the phosphorylation of Ca2+ channel proteins and further alteration of Ca2+ influx.

Original languageEnglish
Pages (from-to)227-233
Number of pages7
JournalTrends in Endocrinology & Metabolism
Volume5
Issue number6
DOIs
Publication statusPublished - 1 Jan 1994
Externally publishedYes

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