O-substituted alkyl aldehydes for rhodium-catalyzed intermolecular alkyne hydroacylation: the utility of methylthiomethyl ethers

Scott R. Parsons, Joel F. Hooper, Michael C. Willis

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Combining α-methylthiomethyl (MTM) ether substituted aldehydes and 1-alkynes in the presence of [Rh(dppe)]ClO 4 results in efficient intermolecular alkyne hydroacylation to deliver α-O-MTM-substituted enone products. The product MTM ethers can be converted to the free hydroxyl group either in situ, by the addition of water to the completed reaction, or in a separate operation, by the action of silver nitrate.
Original languageEnglish
Pages (from-to)998-1000
Number of pages3
JournalOrganic Letters
Issue number5
Publication statusPublished - 4 Mar 2011
Externally publishedYes

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