Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 463-476 |
| Number of pages | 14 |
| Journal | Trends in Microbiology |
| Volume | 24 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2016 |
Keywords
- antibiotic-associated diarrhoea
- bacteria
- antibiotics
- antibiotic resistance
Cite this
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Involvement of bacteria other than Clostridium difficile in antibiotic-associated diarrhoea. / Larcombe, Sarah; Hutton, Melanie L.; Lyras, Dena.
In: Trends in Microbiology, Vol. 24, No. 6, 06.2016, p. 463-476.Research output: Contribution to journal › Review Article › Research › peer-review
TY - JOUR
T1 - Involvement of bacteria other than Clostridium difficile in antibiotic-associated diarrhoea
AU - Larcombe, Sarah
AU - Hutton, Melanie L.
AU - Lyras, Dena
PY - 2016/6
Y1 - 2016/6
N2 - Antibiotic-associated diarrhoea (AAD) is a common and unintended consequence of antibiotic use. Clostridium difficile is the most common infectious aetiology of AAD; however, only approximately 25% of all AAD cases are associated with C. difficile infection, with the aetiology in the majority of cases remaining undetermined. Numerous other bacterial infectious agents have been implicated in AAD, including Clostridium perfringens, Staphylococcus aureus, and Klebsiella oxytoca. AAD is a complex disease that is influenced by the host, the infectious agent involved, and numerous clinical factors, including antibiotic treatment regimes. This review re-examines AAD and presents current perspectives on this disease, with a particular focus on the current understanding of bacterial causes other than C. difficile and the virulence factors involved in pathogenesis.
AB - Antibiotic-associated diarrhoea (AAD) is a common and unintended consequence of antibiotic use. Clostridium difficile is the most common infectious aetiology of AAD; however, only approximately 25% of all AAD cases are associated with C. difficile infection, with the aetiology in the majority of cases remaining undetermined. Numerous other bacterial infectious agents have been implicated in AAD, including Clostridium perfringens, Staphylococcus aureus, and Klebsiella oxytoca. AAD is a complex disease that is influenced by the host, the infectious agent involved, and numerous clinical factors, including antibiotic treatment regimes. This review re-examines AAD and presents current perspectives on this disease, with a particular focus on the current understanding of bacterial causes other than C. difficile and the virulence factors involved in pathogenesis.
KW - antibiotic-associated diarrhoea
KW - bacteria
KW - antibiotics
KW - antibiotic resistance
UR - http://www.ncbi.nlm.nih.gov/pubmed/26897710
U2 - 10.1016/j.tim.2016.02.001
DO - 10.1016/j.tim.2016.02.001
M3 - Review Article
VL - 24
SP - 463
EP - 476
JO - Trends in Microbiology
JF - Trends in Microbiology
SN - 0966-842X
IS - 6
ER -