Involvement of bacteria other than Clostridium difficile in antibiotic-associated diarrhoea

Research output: Contribution to journalReview ArticleResearchpeer-review

29 Citations (Scopus)

Abstract

Antibiotic-associated diarrhoea (AAD) is a common and unintended consequence of antibiotic use. Clostridium difficile is the most common infectious aetiology of AAD; however, only approximately 25% of all AAD cases are associated with C. difficile infection, with the aetiology in the majority of cases remaining undetermined. Numerous other bacterial infectious agents have been implicated in AAD, including Clostridium perfringens, Staphylococcus aureus, and Klebsiella oxytoca. AAD is a complex disease that is influenced by the host, the infectious agent involved, and numerous clinical factors, including antibiotic treatment regimes. This review re-examines AAD and presents current perspectives on this disease, with a particular focus on the current understanding of bacterial causes other than C. difficile and the virulence factors involved in pathogenesis.
Original languageEnglish
Pages (from-to)463-476
Number of pages14
JournalTrends in Microbiology
Volume24
Issue number6
DOIs
Publication statusPublished - Jun 2016

Keywords

  • antibiotic-associated diarrhoea
  • bacteria
  • antibiotics
  • antibiotic resistance

Cite this

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title = "Involvement of bacteria other than Clostridium difficile in antibiotic-associated diarrhoea",
abstract = "Antibiotic-associated diarrhoea (AAD) is a common and unintended consequence of antibiotic use. Clostridium difficile is the most common infectious aetiology of AAD; however, only approximately 25{\%} of all AAD cases are associated with C. difficile infection, with the aetiology in the majority of cases remaining undetermined. Numerous other bacterial infectious agents have been implicated in AAD, including Clostridium perfringens, Staphylococcus aureus, and Klebsiella oxytoca. AAD is a complex disease that is influenced by the host, the infectious agent involved, and numerous clinical factors, including antibiotic treatment regimes. This review re-examines AAD and presents current perspectives on this disease, with a particular focus on the current understanding of bacterial causes other than C. difficile and the virulence factors involved in pathogenesis.",
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author = "Sarah Larcombe and Hutton, {Melanie L.} and Dena Lyras",
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Involvement of bacteria other than Clostridium difficile in antibiotic-associated diarrhoea. / Larcombe, Sarah; Hutton, Melanie L.; Lyras, Dena.

In: Trends in Microbiology, Vol. 24, No. 6, 06.2016, p. 463-476.

Research output: Contribution to journalReview ArticleResearchpeer-review

TY - JOUR

T1 - Involvement of bacteria other than Clostridium difficile in antibiotic-associated diarrhoea

AU - Larcombe, Sarah

AU - Hutton, Melanie L.

AU - Lyras, Dena

PY - 2016/6

Y1 - 2016/6

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AB - Antibiotic-associated diarrhoea (AAD) is a common and unintended consequence of antibiotic use. Clostridium difficile is the most common infectious aetiology of AAD; however, only approximately 25% of all AAD cases are associated with C. difficile infection, with the aetiology in the majority of cases remaining undetermined. Numerous other bacterial infectious agents have been implicated in AAD, including Clostridium perfringens, Staphylococcus aureus, and Klebsiella oxytoca. AAD is a complex disease that is influenced by the host, the infectious agent involved, and numerous clinical factors, including antibiotic treatment regimes. This review re-examines AAD and presents current perspectives on this disease, with a particular focus on the current understanding of bacterial causes other than C. difficile and the virulence factors involved in pathogenesis.

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KW - bacteria

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KW - antibiotic resistance

UR - http://www.ncbi.nlm.nih.gov/pubmed/26897710

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DO - 10.1016/j.tim.2016.02.001

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JO - Trends in Microbiology

JF - Trends in Microbiology

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