Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation

Chrishan S Samuel, Ishanee Mookerjee, Michelle Louise Halls, Roger James Summers, Elaine Chew, Ross A D Bathgate, Geoffrey W Tregear, Tim D Hewitson

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Derived from fibroblasts, myofibroblasts are the principal cells that are responsible for the synthesis and reorganization of excess matrix in renal interstitial fibrosis. Recognized from their de novo expression of alpha-smooth muscle actin, myofibroblast differentiation and activity can be influenced by several factors, including a combination of growth factors and other soluble mediators, extracellular matrix components, and mechanical stress. Relaxin has previously been shown to inhibit renal myofibroblast differentiation in vitro, an effect partly mediated through its ability to interfere with the transforming growth factor-beta1 (TGF-beta1) pathway via inhibition of Smad2 phosphorylation and translocation. Furthermore, endogenous relaxin has been shown to protect the kidney from a myofibroblast-mediated model of injury in vivo. However, the pathways involved in the interaction between relaxin and TGF-beta1 remain unknown. In this report, the inhibitory actions of relaxin on TGF-beta1-induced renal myofibroblast differentiation are summarized to date, and the potential signaling pathways that are implicated in relaxin s inhibitory actions are discussed.
Original languageEnglish
Pages (from-to)294 - 299
Number of pages6
JournalAnnals of the New York Academy of Sciences
Volume1160
DOIs
Publication statusPublished - 2009

Cite this

Samuel, Chrishan S ; Mookerjee, Ishanee ; Halls, Michelle Louise ; Summers, Roger James ; Chew, Elaine ; Bathgate, Ross A D ; Tregear, Geoffrey W ; Hewitson, Tim D. / Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation. In: Annals of the New York Academy of Sciences. 2009 ; Vol. 1160. pp. 294 - 299.
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abstract = "Derived from fibroblasts, myofibroblasts are the principal cells that are responsible for the synthesis and reorganization of excess matrix in renal interstitial fibrosis. Recognized from their de novo expression of alpha-smooth muscle actin, myofibroblast differentiation and activity can be influenced by several factors, including a combination of growth factors and other soluble mediators, extracellular matrix components, and mechanical stress. Relaxin has previously been shown to inhibit renal myofibroblast differentiation in vitro, an effect partly mediated through its ability to interfere with the transforming growth factor-beta1 (TGF-beta1) pathway via inhibition of Smad2 phosphorylation and translocation. Furthermore, endogenous relaxin has been shown to protect the kidney from a myofibroblast-mediated model of injury in vivo. However, the pathways involved in the interaction between relaxin and TGF-beta1 remain unknown. In this report, the inhibitory actions of relaxin on TGF-beta1-induced renal myofibroblast differentiation are summarized to date, and the potential signaling pathways that are implicated in relaxin s inhibitory actions are discussed.",
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Investigations into the inhibitory effects of relaxin on renal myofibroblast differentiation. / Samuel, Chrishan S; Mookerjee, Ishanee; Halls, Michelle Louise; Summers, Roger James; Chew, Elaine; Bathgate, Ross A D; Tregear, Geoffrey W; Hewitson, Tim D.

In: Annals of the New York Academy of Sciences, Vol. 1160, 2009, p. 294 - 299.

Research output: Contribution to journalArticleResearchpeer-review

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