Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7 T

Laurentius Huber, Jozien B M Goense, Aneurin James Kennerley, Dimo Ivanov, Steffen Norbert Krieger, Joran Lepsien, Robert Trampel, Robert W Turner, Harald E Moller

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Abstract

Decreases in stimulus-dependent blood oxygenation level dependent (BOLD) signal and their underlying neurovascular origins have recently gained considerable interest. In this study a multi-echo, BOLD-corrected vascular space occupancy (VASO) functional magnetic resonance imaging (fMRI) technique was used to investigate neurovascular responses during stimuli that elicit positive and negative BOLD responses in human brain at 7. T. Stimulus-induced BOLD, cerebral blood volume (CBV), and cerebral blood flow (CBF) changes were measured and analyzed in arterial and venous blood compartments in macro- and microvasculature. We found that the overall interplay of mean CBV, CBF and BOLD responses is similar for tasks inducing positive and negative BOLD responses. Some aspects of the neurovascular coupling however, such as the temporal response, cortical depth dependence, and the weighting between arterial and venous contributions, are significantly different for the different task conditions. Namely, while for excitatory tasks the BOLD response peaks at the cortical surface, and the CBV change is similar in cortex and pial vasculature, inhibitory tasks are associated with a maximum negative BOLD response in deeper layers, with CBV showing strong constriction of surface arteries and a faster return to baseline. The different interplays of CBV, CBF and BOLD during excitatory and inhibitory responses suggests different underlying hemodynamic mechanisms
Original languageEnglish
Pages (from-to)349 - 362
Number of pages14
JournalNeuroImage
Volume97
DOIs
Publication statusPublished - 2014

Cite this

Huber, L., Goense, J. B. M., Kennerley, A. J., Ivanov, D., Krieger, S. N., Lepsien, J., ... Moller, H. E. (2014). Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7 T. NeuroImage, 97, 349 - 362. https://doi.org/10.1016/j.neuroimage.2014.04.022
Huber, Laurentius ; Goense, Jozien B M ; Kennerley, Aneurin James ; Ivanov, Dimo ; Krieger, Steffen Norbert ; Lepsien, Joran ; Trampel, Robert ; Turner, Robert W ; Moller, Harald E. / Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7 T. In: NeuroImage. 2014 ; Vol. 97. pp. 349 - 362.
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title = "Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7 T",
abstract = "Decreases in stimulus-dependent blood oxygenation level dependent (BOLD) signal and their underlying neurovascular origins have recently gained considerable interest. In this study a multi-echo, BOLD-corrected vascular space occupancy (VASO) functional magnetic resonance imaging (fMRI) technique was used to investigate neurovascular responses during stimuli that elicit positive and negative BOLD responses in human brain at 7. T. Stimulus-induced BOLD, cerebral blood volume (CBV), and cerebral blood flow (CBF) changes were measured and analyzed in arterial and venous blood compartments in macro- and microvasculature. We found that the overall interplay of mean CBV, CBF and BOLD responses is similar for tasks inducing positive and negative BOLD responses. Some aspects of the neurovascular coupling however, such as the temporal response, cortical depth dependence, and the weighting between arterial and venous contributions, are significantly different for the different task conditions. Namely, while for excitatory tasks the BOLD response peaks at the cortical surface, and the CBV change is similar in cortex and pial vasculature, inhibitory tasks are associated with a maximum negative BOLD response in deeper layers, with CBV showing strong constriction of surface arteries and a faster return to baseline. The different interplays of CBV, CBF and BOLD during excitatory and inhibitory responses suggests different underlying hemodynamic mechanisms",
author = "Laurentius Huber and Goense, {Jozien B M} and Kennerley, {Aneurin James} and Dimo Ivanov and Krieger, {Steffen Norbert} and Joran Lepsien and Robert Trampel and Turner, {Robert W} and Moller, {Harald E}",
year = "2014",
doi = "10.1016/j.neuroimage.2014.04.022",
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Huber, L, Goense, JBM, Kennerley, AJ, Ivanov, D, Krieger, SN, Lepsien, J, Trampel, R, Turner, RW & Moller, HE 2014, 'Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7 T', NeuroImage, vol. 97, pp. 349 - 362. https://doi.org/10.1016/j.neuroimage.2014.04.022

Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7 T. / Huber, Laurentius; Goense, Jozien B M; Kennerley, Aneurin James; Ivanov, Dimo; Krieger, Steffen Norbert; Lepsien, Joran; Trampel, Robert; Turner, Robert W; Moller, Harald E.

In: NeuroImage, Vol. 97, 2014, p. 349 - 362.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Investigation of the neurovascular coupling in positive and negative BOLD responses in human brain at 7 T

AU - Huber, Laurentius

AU - Goense, Jozien B M

AU - Kennerley, Aneurin James

AU - Ivanov, Dimo

AU - Krieger, Steffen Norbert

AU - Lepsien, Joran

AU - Trampel, Robert

AU - Turner, Robert W

AU - Moller, Harald E

PY - 2014

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N2 - Decreases in stimulus-dependent blood oxygenation level dependent (BOLD) signal and their underlying neurovascular origins have recently gained considerable interest. In this study a multi-echo, BOLD-corrected vascular space occupancy (VASO) functional magnetic resonance imaging (fMRI) technique was used to investigate neurovascular responses during stimuli that elicit positive and negative BOLD responses in human brain at 7. T. Stimulus-induced BOLD, cerebral blood volume (CBV), and cerebral blood flow (CBF) changes were measured and analyzed in arterial and venous blood compartments in macro- and microvasculature. We found that the overall interplay of mean CBV, CBF and BOLD responses is similar for tasks inducing positive and negative BOLD responses. Some aspects of the neurovascular coupling however, such as the temporal response, cortical depth dependence, and the weighting between arterial and venous contributions, are significantly different for the different task conditions. Namely, while for excitatory tasks the BOLD response peaks at the cortical surface, and the CBV change is similar in cortex and pial vasculature, inhibitory tasks are associated with a maximum negative BOLD response in deeper layers, with CBV showing strong constriction of surface arteries and a faster return to baseline. The different interplays of CBV, CBF and BOLD during excitatory and inhibitory responses suggests different underlying hemodynamic mechanisms

AB - Decreases in stimulus-dependent blood oxygenation level dependent (BOLD) signal and their underlying neurovascular origins have recently gained considerable interest. In this study a multi-echo, BOLD-corrected vascular space occupancy (VASO) functional magnetic resonance imaging (fMRI) technique was used to investigate neurovascular responses during stimuli that elicit positive and negative BOLD responses in human brain at 7. T. Stimulus-induced BOLD, cerebral blood volume (CBV), and cerebral blood flow (CBF) changes were measured and analyzed in arterial and venous blood compartments in macro- and microvasculature. We found that the overall interplay of mean CBV, CBF and BOLD responses is similar for tasks inducing positive and negative BOLD responses. Some aspects of the neurovascular coupling however, such as the temporal response, cortical depth dependence, and the weighting between arterial and venous contributions, are significantly different for the different task conditions. Namely, while for excitatory tasks the BOLD response peaks at the cortical surface, and the CBV change is similar in cortex and pial vasculature, inhibitory tasks are associated with a maximum negative BOLD response in deeper layers, with CBV showing strong constriction of surface arteries and a faster return to baseline. The different interplays of CBV, CBF and BOLD during excitatory and inhibitory responses suggests different underlying hemodynamic mechanisms

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U2 - 10.1016/j.neuroimage.2014.04.022

DO - 10.1016/j.neuroimage.2014.04.022

M3 - Article

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JO - NeuroImage

JF - NeuroImage

SN - 1053-8119

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