Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties

Qi Zhou, Li Qu, Thomas Gegenbach, John Denman, Ian Larson, Peter Stewart, David Morton

Research output: Contribution to journalArticleResearchpeer-review

45 Citations (Scopus)

Abstract

The objective of this study was to investigate if the coating extent created by a mechanofusion process corresponded with observed changes in bulk powder properties. A fine lactose powder (approximate median diameter 20 I?m) was dry coated with magnesium stearate using from 0.1 to 5 (w/w) content. An ultra-thin coating layer of magnesium stearate was anticipated, but previous attempts to determine such thin layers on these fine particles have had limited success, with poor resolution. In this study, the surface coating was examined using the state-of-the-art XPS and ToF-SIMS systems. The powder flow was characterized by Carr index and shear cell testing. XPS was successfully applied to demonstrate variations in surface coverage, as a function of additive levels, and indicated near complete coating coverage at additive levels of 1 (w/w) and above. ToF-SIMS results supported such coating coverage assessment, and indicated coating uniformly across the fine particle surfaces. The flow metrics employed could then be related to the coating coverage metrics. The mechanofusion process also modified the apparent surface roughness observed by SEM and BET. It was suggested that the changes in the surface chemical composition exerted a more evident and direct impact on the powder cohesion and flow characteristics than the changes in the surface morphological properties after the mechanofusion in this study.
Original languageEnglish
Pages (from-to)36 - 43
Number of pages8
JournalInternational Journal of Pharmaceutics
Volume413
DOIs
Publication statusPublished - 2011

Cite this

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title = "Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties",
abstract = "The objective of this study was to investigate if the coating extent created by a mechanofusion process corresponded with observed changes in bulk powder properties. A fine lactose powder (approximate median diameter 20 I?m) was dry coated with magnesium stearate using from 0.1 to 5 (w/w) content. An ultra-thin coating layer of magnesium stearate was anticipated, but previous attempts to determine such thin layers on these fine particles have had limited success, with poor resolution. In this study, the surface coating was examined using the state-of-the-art XPS and ToF-SIMS systems. The powder flow was characterized by Carr index and shear cell testing. XPS was successfully applied to demonstrate variations in surface coverage, as a function of additive levels, and indicated near complete coating coverage at additive levels of 1 (w/w) and above. ToF-SIMS results supported such coating coverage assessment, and indicated coating uniformly across the fine particle surfaces. The flow metrics employed could then be related to the coating coverage metrics. The mechanofusion process also modified the apparent surface roughness observed by SEM and BET. It was suggested that the changes in the surface chemical composition exerted a more evident and direct impact on the powder cohesion and flow characteristics than the changes in the surface morphological properties after the mechanofusion in this study.",
author = "Qi Zhou and Li Qu and Thomas Gegenbach and John Denman and Ian Larson and Peter Stewart and David Morton",
year = "2011",
doi = "10.1016/j.ijpharm.2011.04.014",
language = "English",
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pages = "36 -- 43",
journal = "International Journal of Pharmaceutics",
issn = "0378-5173",
publisher = "Elsevier",

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Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties. / Zhou, Qi; Qu, Li; Gegenbach, Thomas; Denman, John; Larson, Ian; Stewart, Peter; Morton, David.

In: International Journal of Pharmaceutics, Vol. 413, 2011, p. 36 - 43.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Investigation of the extent of surface coating via mechanofusion with varying additive levels and the influences on bulk powder flow properties

AU - Zhou, Qi

AU - Qu, Li

AU - Gegenbach, Thomas

AU - Denman, John

AU - Larson, Ian

AU - Stewart, Peter

AU - Morton, David

PY - 2011

Y1 - 2011

N2 - The objective of this study was to investigate if the coating extent created by a mechanofusion process corresponded with observed changes in bulk powder properties. A fine lactose powder (approximate median diameter 20 I?m) was dry coated with magnesium stearate using from 0.1 to 5 (w/w) content. An ultra-thin coating layer of magnesium stearate was anticipated, but previous attempts to determine such thin layers on these fine particles have had limited success, with poor resolution. In this study, the surface coating was examined using the state-of-the-art XPS and ToF-SIMS systems. The powder flow was characterized by Carr index and shear cell testing. XPS was successfully applied to demonstrate variations in surface coverage, as a function of additive levels, and indicated near complete coating coverage at additive levels of 1 (w/w) and above. ToF-SIMS results supported such coating coverage assessment, and indicated coating uniformly across the fine particle surfaces. The flow metrics employed could then be related to the coating coverage metrics. The mechanofusion process also modified the apparent surface roughness observed by SEM and BET. It was suggested that the changes in the surface chemical composition exerted a more evident and direct impact on the powder cohesion and flow characteristics than the changes in the surface morphological properties after the mechanofusion in this study.

AB - The objective of this study was to investigate if the coating extent created by a mechanofusion process corresponded with observed changes in bulk powder properties. A fine lactose powder (approximate median diameter 20 I?m) was dry coated with magnesium stearate using from 0.1 to 5 (w/w) content. An ultra-thin coating layer of magnesium stearate was anticipated, but previous attempts to determine such thin layers on these fine particles have had limited success, with poor resolution. In this study, the surface coating was examined using the state-of-the-art XPS and ToF-SIMS systems. The powder flow was characterized by Carr index and shear cell testing. XPS was successfully applied to demonstrate variations in surface coverage, as a function of additive levels, and indicated near complete coating coverage at additive levels of 1 (w/w) and above. ToF-SIMS results supported such coating coverage assessment, and indicated coating uniformly across the fine particle surfaces. The flow metrics employed could then be related to the coating coverage metrics. The mechanofusion process also modified the apparent surface roughness observed by SEM and BET. It was suggested that the changes in the surface chemical composition exerted a more evident and direct impact on the powder cohesion and flow characteristics than the changes in the surface morphological properties after the mechanofusion in this study.

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