Investigation of the biological properties of Cinnulin PF in the context of diabetes: mechanistic insights by genome-wide mRNA-Seq analysis

Haloom Rafehi, Katherine Ververis, Aneta Balcerczyk, Mark Ziemann, Jenny Ooi, Sean Hu, Faith Kwa, Shanon J. Loveridge, George T. Georgiadis, Assam El-Osta, Tomas Karagiannis

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The accumulating evidence of the beneficial effects of cinnamon (Cinnamomum burmanni) in type-2 diabetes,a chronic age-associated disease, has prompted the commercialisation of various supplemental forms of the spice. One such supplement, Cinnulin PF†, represents the water soluble fraction containing relatively high levels of the double-linked procyanidin type-A polymers of flavanoids. The overall aim of this study was toutilize genome-wide mRNA-Seq analysis to characterise the changes in gene expression caused by CinnulinPF in immortalised human keratinocytes and microvascular endothelial cells, which are relevant with respect to diabetic complications. In summary, our findings provide insights into the mechanisms of action of Cinnulin PF in diabetes and diabetic complications. More generally, we identify relevant candidate genes which could provide the basis for further investigation.
Original languageEnglish
Article number11905
Number of pages14
JournalPathobiology of Aging & Age-related Diseases
Issue number1
Publication statusPublished - 2012


  • cinnulin PF
  • diabetes
  • diabetic complications
  • diabetic ulcer
  • mRNA-Seq

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