Investigation of the applicability of dielectric relaxation properties of amino acid solutions within the resonant recognition model

Elena Pirogova, George P. Simon, Irena Cosic

Research output: Contribution to journalArticleResearchpeer-review

29 Citations (Scopus)

Abstract

The resonant recognition model (RRM) is a physico-mathematical approach used to analyze the interactions of a protein and its target, using digital signal processing methods. The RRM is based on the finding that there is a significant correlation between the spectra of numerical presentation of protein sequences and their biological activities. Initially, the electron-ion interaction potential was used to represent each amino acid in the protein sequences. In this paper, the dielectric constant (ε′) and dielectric loss tangent (tan δ) parameters have been determined for their possible use in the RRM. These parameters are based on the values of capacitance and conductance obtained experimentally for 20 amino acid solutions using dielectric spectroscopy for the case of the real component of dielectric permittivity; the parameter used is the dielectric increment (Δε′), the difference between dielectric constant of the amino acid solution and that of the solvent alone. The results of multiple cross-spectral analyses have shown that parameters analyzed generate in the consensus spectrum one dominant peak corresponding to the common biological activity of proteins studied, allowing the conclusion that these new parameters are suitable for use in the RRM approach.

Original languageEnglish
Pages (from-to)63-69
Number of pages7
JournalIEEE Transactions on NanoBioscience
Volume2
Issue number2
DOIs
Publication statusPublished - 1 Jun 2003

Keywords

  • Amino acids
  • Dielectric relaxation
  • Digital signal processing
  • Protein conductivity
  • Protein function

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