Investigation of p16 status, chemotherapy regimen, and other nutrition markers for predicting gastrostomy in patients with head and neck cancer

Teresa E. Brown, Kym Wittholz, Mandy Way, Merrilyn D. Banks, Brett G.M. Hughes, Charles Y. Lin, Lizbeth M. Kenny, Judith D. Bauer

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

Background: The purpose of this study was to determine if p16 status, chemotherapy regimen, or other nutrition markers could improve protocol accuracy in predicting proactive gastrostomy in patients with head and neck cancer. Methods: Patients who received curative treatment from July 2010 to June 2011 were included (n = 269). Associations among dependent variables (age, sex, tumor site, staging, treatment, p16 status, albumin, and Malnutrition Screening Tool [MST] score), the protocol risk rating, and requirement for proactive gastrostomy were examined. Results: Current protocol correctly identified 81 of 88 high-risk patients (92%) for gastrostomy, but incorrectly classified 32 of 181 low-risk patients (18%). Analysis of low-risk patients with oral or oropharyngeal cancers, found p16-positive disease had 4.4 times greater odds (p =.049), and those at risk of malnutrition had 4.5 times greater odds (p =.019) of requiring gastrostomy. Conclusion: Malnutrition risk and p16 status could be used to identify further patients who may benefit from proactive gastrostomy.

Original languageEnglish
Pages (from-to)868-875
Number of pages8
JournalHead and Neck
Volume39
Issue number5
DOIs
Publication statusPublished - May 2017
Externally publishedYes

Keywords

  • chemotherapy
  • gastrostomy
  • head and neck cancer
  • human papillomavirus (HPV)
  • malnutrition

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