Investigation of determinants of atypical femoral fractures using Multiscale computational modeling

Saulo Martelli, Peter Pivonka, P. R. Ebeling

Research output: Chapter in Book/Report/Conference proceedingConference PaperResearchpeer-review

Abstract

Atypical femoral fractures (AFF) are predominantly transverse stress fractures from the lateral aspect of the subtrochanteric and diaphyseal region for which long-term bisphosphonate treatment have been suggested an important determinants. However, the physiological loading environment triggering AFFs in typical femoral regions remain largely unexplored. The aim of this study was to test the hypothesis that typical AFFs onset location is associated with high daily cyclic tensile strains. The study was based on body- and organlevel models from a single donor (female, 81- years- old) and motion data recorded from a body-matched volunteer (female, 25 years-old). Models were the donor’s lower-limb musculoskeletal model validated against published measurements of the hip reaction force and the finite-element model of the donor’s right femur validated against measurements of cortical strains. Motion data including skin marker trajectories and ground reaction forces were recorded from the volunteer during walking, which is the most frequent daily activity. The muscle and hip forces were calculated using the musculoskeletal model and applied to the finite-element model to calculate the cortical tensile and compressive strains in two extreme sections of the femoral diaphysis. The anterior, medial, posterior and lateral femoral aspects were assumed at 0°, 90°, 180°, and 270° respectively. In the sub-trochanteric section the peak tensile strain during stance was 1300-2287 με constantly located laterally (270°-300°) and the peak compressive strain was 1433-2730 με constantly located medially (90°). In the distal diaphysis the peak tensile strain varied from 1714 με to 4171 με located antero-laterally at 300°-330° and the peak compressive strain varied from 1813 μεto 4674 με located posteromedially (90°-150°). We conclude that high cyclic tensile strains determine the typical AFFs onset location whereas more research is necessary to understand how different activities and the individual anatomy affect the femur’s physiological tensile loads.

Original languageEnglish
Title of host publicationThe 15th International Conference on Biomedical Engineering, ICBME 2013
EditorsJames Goh
PublisherSpringer
Pages323-326
Number of pages4
ISBN (Electronic)9783319029122, 9783319029139
DOIs
Publication statusPublished - 2014
Externally publishedYes
EventInternational Conference on Biomedical Engineering (ICBME) 2013 - Singapore, Singapore
Duration: 4 Dec 20137 Dec 2013
Conference number: 15th
http://www.springer.com/gp/book/9783319029122 (Springer Conference Proceedings)

Publication series

NameIFMBE Proceedings
PublisherSpringer
Volume43
ISSN (Print)1680-0737
ISSN (Electronic)1433-9277

Conference

ConferenceInternational Conference on Biomedical Engineering (ICBME) 2013
Abbreviated titleICMBE 2013
Country/TerritorySingapore
CitySingapore
Period4/12/137/12/13
Internet address

Keywords

  • Atypical femoral fracture
  • Bone strains
  • Finite-element models
  • Musculoskeletal simulation
  • Walking

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