Abstract
Colistin, a cyclic polypeptide linked to a fatty acyl tail, is an old antibiotic with potential toxicity when administered intravenously; however, for treating lung infections, dry powder inhalers (DPIs) have potential to deliver high doses directly to the site of infection. This study has examined the potential to engineer microparticles of colistin, with optimised surface energy, to create particles for effective use in DPIs. Methods: Spray dried colistin sulphate powders were obtained using a Buchi Mini-Spray Drier 190. Inverse Gas Chromatography (IGC) was used to determine the surface energies of the different particles. In vitro dispersion efficiency was measured by aerosolising into a twin stage impinger.
| Original language | English |
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| Title of host publication | Proceedings of the 1st Electronic Conference on Pharmaceutical Sciences |
| Editors | Jely He |
| Place of Publication | Basel, Switzerland |
| Publisher | MDPI AG |
| Pages | 1 - 6 |
| Number of pages | 6 |
| Publication status | Published - 2011 |
| Event | Electronic Conference on Pharmaceutical Sciences (ECPS 2011) - Basel, Switzerland Duration: 1 Mar 2011 → 31 Mar 2011 Conference number: 1st |
Conference
| Conference | Electronic Conference on Pharmaceutical Sciences (ECPS 2011) |
|---|---|
| Abbreviated title | ECPS 2011 |
| Country | Switzerland |
| City | Basel |
| Period | 1/03/11 → 31/03/11 |
| Other | This was an electronic conference so has no actual location of conference, however the evidence indicates that the proceedings were published by MDPI in Switzerland |