Investigating the particle engineering of colistin for pulmonary delivery

Teresa Jong, Jian Li, John Hale, David Morton, Ian Larson

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

Abstract

Colistin, a cyclic polypeptide linked to a fatty acyl tail, is an old antibiotic with potential toxicity when administered intravenously; however, for treating lung infections, dry powder inhalers (DPIs) have potential to deliver high doses directly to the site of infection. This study has examined the potential to engineer microparticles of colistin, with optimised surface energy, to create particles for effective use in DPIs. Methods: Spray dried colistin sulphate powders were obtained using a Buchi Mini-Spray Drier 190. Inverse Gas Chromatography (IGC) was used to determine the surface energies of the different particles. In vitro dispersion efficiency was measured by aerosolising into a twin stage impinger.
Original languageEnglish
Title of host publicationProceedings of the 1st Electronic Conference on Pharmaceutical Sciences
EditorsJely He
Place of PublicationBasel, Switzerland
PublisherMDPI AG
Pages1 - 6
Number of pages6
Publication statusPublished - 2011
EventElectronic Conference on Pharmaceutical Sciences (ECPS 2011) - Basel, Switzerland
Duration: 1 Mar 201131 Mar 2011
Conference number: 1st

Conference

ConferenceElectronic Conference on Pharmaceutical Sciences (ECPS 2011)
Abbreviated titleECPS 2011
CountrySwitzerland
CityBasel
Period1/03/1131/03/11
OtherThis was an electronic conference so has no actual location of conference, however the evidence indicates that the proceedings were published by MDPI in Switzerland

Cite this

Jong, T., Li, J., Hale, J., Morton, D., & Larson, I. (2011). Investigating the particle engineering of colistin for pulmonary delivery. In J. He (Ed.), Proceedings of the 1st Electronic Conference on Pharmaceutical Sciences (pp. 1 - 6). Basel, Switzerland: MDPI AG.
Jong, Teresa ; Li, Jian ; Hale, John ; Morton, David ; Larson, Ian. / Investigating the particle engineering of colistin for pulmonary delivery. Proceedings of the 1st Electronic Conference on Pharmaceutical Sciences. editor / Jely He. Basel, Switzerland : MDPI AG, 2011. pp. 1 - 6
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abstract = "Colistin, a cyclic polypeptide linked to a fatty acyl tail, is an old antibiotic with potential toxicity when administered intravenously; however, for treating lung infections, dry powder inhalers (DPIs) have potential to deliver high doses directly to the site of infection. This study has examined the potential to engineer microparticles of colistin, with optimised surface energy, to create particles for effective use in DPIs. Methods: Spray dried colistin sulphate powders were obtained using a Buchi Mini-Spray Drier 190. Inverse Gas Chromatography (IGC) was used to determine the surface energies of the different particles. In vitro dispersion efficiency was measured by aerosolising into a twin stage impinger.",
author = "Teresa Jong and Jian Li and John Hale and David Morton and Ian Larson",
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language = "English",
pages = "1 -- 6",
editor = "Jely He",
booktitle = "Proceedings of the 1st Electronic Conference on Pharmaceutical Sciences",
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Jong, T, Li, J, Hale, J, Morton, D & Larson, I 2011, Investigating the particle engineering of colistin for pulmonary delivery. in J He (ed.), Proceedings of the 1st Electronic Conference on Pharmaceutical Sciences. MDPI AG, Basel, Switzerland, pp. 1 - 6, Electronic Conference on Pharmaceutical Sciences (ECPS 2011), Basel, Switzerland, 1/03/11.

Investigating the particle engineering of colistin for pulmonary delivery. / Jong, Teresa; Li, Jian; Hale, John; Morton, David; Larson, Ian.

Proceedings of the 1st Electronic Conference on Pharmaceutical Sciences. ed. / Jely He. Basel, Switzerland : MDPI AG, 2011. p. 1 - 6.

Research output: Chapter in Book/Report/Conference proceedingConference PaperOtherpeer-review

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T1 - Investigating the particle engineering of colistin for pulmonary delivery

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AU - Li, Jian

AU - Hale, John

AU - Morton, David

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N2 - Colistin, a cyclic polypeptide linked to a fatty acyl tail, is an old antibiotic with potential toxicity when administered intravenously; however, for treating lung infections, dry powder inhalers (DPIs) have potential to deliver high doses directly to the site of infection. This study has examined the potential to engineer microparticles of colistin, with optimised surface energy, to create particles for effective use in DPIs. Methods: Spray dried colistin sulphate powders were obtained using a Buchi Mini-Spray Drier 190. Inverse Gas Chromatography (IGC) was used to determine the surface energies of the different particles. In vitro dispersion efficiency was measured by aerosolising into a twin stage impinger.

AB - Colistin, a cyclic polypeptide linked to a fatty acyl tail, is an old antibiotic with potential toxicity when administered intravenously; however, for treating lung infections, dry powder inhalers (DPIs) have potential to deliver high doses directly to the site of infection. This study has examined the potential to engineer microparticles of colistin, with optimised surface energy, to create particles for effective use in DPIs. Methods: Spray dried colistin sulphate powders were obtained using a Buchi Mini-Spray Drier 190. Inverse Gas Chromatography (IGC) was used to determine the surface energies of the different particles. In vitro dispersion efficiency was measured by aerosolising into a twin stage impinger.

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BT - Proceedings of the 1st Electronic Conference on Pharmaceutical Sciences

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Jong T, Li J, Hale J, Morton D, Larson I. Investigating the particle engineering of colistin for pulmonary delivery. In He J, editor, Proceedings of the 1st Electronic Conference on Pharmaceutical Sciences. Basel, Switzerland: MDPI AG. 2011. p. 1 - 6