TY - JOUR
T1 - Investigating the interactions of amino acid components on a mannitol-based spray-dried powder formulation for pulmonary delivery: A design of experiment approach
AU - Sou, Tomas
AU - Orlando, Laurence
AU - McIntosh, Michelle Paula
AU - Kaminskas, Lisa
AU - Morton, David
PY - 2011
Y1 - 2011
N2 - Combining an amino acid and a sugar is a known strategy in the formulation of spray or freeze dried biomolecule powder formulations. The effect of the amino acid leucine in enhancing performance of spray-dried powders has been previously demonstrated, but interaction effects of several constituents which may provide multiple benefits, are less well-understood.
AB - Combining an amino acid and a sugar is a known strategy in the formulation of spray or freeze dried biomolecule powder formulations. The effect of the amino acid leucine in enhancing performance of spray-dried powders has been previously demonstrated, but interaction effects of several constituents which may provide multiple benefits, are less well-understood.
UR - http://www.sciencedirect.com/science/article/pii/S0378517311008672
U2 - 10.1016/j.ijpharm.2011.09.018
DO - 10.1016/j.ijpharm.2011.09.018
M3 - Article
SN - 0378-5173
VL - 421
SP - 220
EP - 229
JO - International Journal of Pharmaceutics
JF - International Journal of Pharmaceutics
IS - 2
ER -