Investigating the interactions of amino acid components on a mannitol-based spray-dried powder formulation for pulmonary delivery: A design of experiment approach

Tomas Sou, Laurence Orlando, Michelle Paula McIntosh, Lisa Kaminskas, David Morton

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Abstract

Combining an amino acid and a sugar is a known strategy in the formulation of spray or freeze dried biomolecule powder formulations. The effect of the amino acid leucine in enhancing performance of spray-dried powders has been previously demonstrated, but interaction effects of several constituents which may provide multiple benefits, are less well-understood.
Original languageEnglish
Pages (from-to)220 - 229
Number of pages10
JournalInternational Journal of Pharmaceutics
Volume421
Issue number2
DOIs
Publication statusPublished - 2011

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