Investigating the interactions between haemopoietic stem cells and their niche: Methods for the analysis of stem cell homing and distribution within the marrow following transplantation

Brenda Williams, Susan Kay Nilsson

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review

8 Citations (Scopus)

Abstract

Interactions between haemopoietic stem cells (HSC) and their microencironment serve multiple functions including the attraction to and retention and regulation in the bone marrow HSC niche. However, the cell adhesion molecules involved, their HSC receptors and the mechanisms underpinning these processes remain poorly understood. An ability to thoroughly investigate the roles of specific molecules in this process relies on a variety of in vitro and in vivo assays including the assessmnt of a HSC ability to home to the bone marrow and analysis of its lodgement within the bone marrow.
Original languageEnglish
Title of host publicationStem Cells in Regenerative Medicine, Methods and Protocols
EditorsJ Audet, W L Stanford
Place of PublicationUSA
PublisherHumana Press
Pages93 - 107
Number of pages15
Edition1
ISBN (Print)9781588297976
Publication statusPublished - 2009

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