TY - GEN
T1 - Investigating the de-agglomeration profiles of dpi formulations
AU - Behara, Srinivas Ravindra Babu
AU - Morton, David
AU - Larson, Ian
AU - Stewart, Peter
AU - Kippax, Paul
PY - 2015/4/1
Y1 - 2015/4/1
N2 - In this paper, Srinivas Ravindra Babu Behara, PhD, Researcher; David Morton, PhD, Associate Professor; Ian Larson, PhD, Senior Lecturer; and Peter Stewart, PhD, Deputy Dean & Professor of Pharmaceutical Sciences, all of Monash University; and Paul Kippax, PhD, Product Group Manager, Malvern Instruments, describe the use of laser diffraction to analyse dry powder behaviour. The authors introduce relative de-agglomeration versus flow rate profiles, which represent an effective graphical means to summarise the outcome of the complex interplay between the applied aerosolisation energy and the cohesive forces opposing dispersion in different powder formulations emitted from different inhalation devices. The resulting data can be used as a screening method for developing a formulation strategy for a particular active substance.
AB - In this paper, Srinivas Ravindra Babu Behara, PhD, Researcher; David Morton, PhD, Associate Professor; Ian Larson, PhD, Senior Lecturer; and Peter Stewart, PhD, Deputy Dean & Professor of Pharmaceutical Sciences, all of Monash University; and Paul Kippax, PhD, Product Group Manager, Malvern Instruments, describe the use of laser diffraction to analyse dry powder behaviour. The authors introduce relative de-agglomeration versus flow rate profiles, which represent an effective graphical means to summarise the outcome of the complex interplay between the applied aerosolisation energy and the cohesive forces opposing dispersion in different powder formulations emitted from different inhalation devices. The resulting data can be used as a screening method for developing a formulation strategy for a particular active substance.
UR - https://www.scopus.com/pages/publications/84930507884
M3 - Article
AN - SCOPUS:84930507884
SN - 2049-145X
VL - 57
SP - 16
EP - 20
JO - ONdrugDelivery
JF - ONdrugDelivery
ER -