TY - JOUR
T1 - Investigating Genetic and Other Determinants of First-Onset Myocardial Infarction in Malaysia
T2 - Protocol for the Malaysian Acute Vascular Events Risk Study
AU - Chowdhury, Rajiv
AU - Md Noh, Mohd Fairulnizal
AU - Ismail, Sophia Rasheeqa
AU - van Daalen, Kim Robin
AU - Megat Kamaruddin, Puteri Sofia Nadira
AU - Zulkiply, Siti Hafizah
AU - Azizul, Nur Hayati
AU - Khalid, Norhayati Mustafa
AU - Ali, Azizan
AU - Idris, Izyan Mohd
AU - Mei, Yong Shih
AU - Abdullah, Shazana Rifham
AU - Faridus, Norfashihah
AU - Md Yusof, Nur Azirah
AU - Yusoff, Nur Najwa Farahin M.
AU - Jamal, Rahman
AU - Abdul Rahim, Aizai Azan
AU - Abdul Ghapar, Abdul Kahar
AU - Radhakrishnan, Ammu Kutty
AU - Yip Fong, Alan Yean
AU - Ismail, Omar
AU - Krishinan, Saravanan
AU - Lee, Chuey Yan
AU - Bang, Liew Houng
AU - Mageswaren, Eashwary
AU - Mahendran, Kauthaman
AU - Mohd Amin, Nor Hanim
AU - Muthusamy, Gunavathy
AU - Hean Jin, Aaron Ong
AU - Ramli, Ahmad Wazi
AU - Ross, Noel Thomas
AU - Ruhani, Anwar Irawan
AU - Yahya, Mansor
AU - Yusoff, Yusniza
AU - Zainal Abidin, Siti Khairani
AU - Amado, Laryssa
AU - Bolton, Thomas
AU - Weston, Sophie
AU - Crawte, Jason
AU - Ovenden, Niko
AU - Michielsen, Ank
AU - Monower, Md Mostafa
AU - Wan Mahiyuddin, Wan Rozita
AU - Wood, Angela
AU - Di Angelantonio, Emanuele
AU - Sulaiman, Nur Suffia
AU - Danesh, John
AU - Butterworth, Adam S.
N1 - Funding Information:
The authors would like to thank the Director General of Health Malaysia for his permission to publish this paper. They also thank Dr Akhmal Yusof and his team at the Clinical Research Malaysia and Dr Carmel Moore and Mr Steve Ellis for their contributions to this study. The views expressed are those of the author(s) and not necessarily those of the National Institute for Health Research (NIHR) or the Department of Health and Social Care. This work was funded by a Medical Research Council-Newton Fund project grant and the Academy of Sciences Malaysia (grant number MR/P013880/1). Biomarker analysis was funded by the National Institutes of Health, Ministry of Health Malaysia (NMRR-16-2399-33768). RC is funded by a Medical Research Council-Newton project grant and the Academy of Sciences Malaysia (grant number MR/P013880/1) and a United Kingdom Research and Innovation-Global Challenges Research Fund Project Grant (CAPABLE) to study the risk factors of noncommunicable diseases in Bangladesh. JC and NO are funded by the NIHR Cambridge Biomedical Research Centre (BRC-1215-20014). TB is funded by the NIHR Blood and Transplant Research Unit in Donor Health and Genomics (NIHR BTRU-2014-10024). KRD is funded by the Gates Cambridge scholarship to conduct her PhD (OPP1144). AW is supported by a BHF-Turing Cardiovascular Data Science award and by the EC-Innovative Medicines Initiative (BigData@Heart). JD holds a British Heart Foundation Professorship and a NIHR Senior Investigator Award. The Cambridge coordinating center for this initiative is supported by core funding from the UK Medical Research Council (MR/L003120/1), British Heart Foundation (RG/13/13/30194; RG/18/13/33946), and NIHR Cambridge BRC (BRC-1215-20014). The data sets generated and analyzed during this study are not currently available in a public repository; however, they are available from the corresponding author upon reasonable request. The code used during this study is available from the corresponding author upon reasonable request. Patients or the public were not involved in the design, conduct, reporting, or dissemination plans of our research.
Publisher Copyright:
©Rajiv Chowdhury, Mohd Fairulnizal Md Noh, Sophia Rasheeqa Ismail, Kim Robin van Daalen, Puteri Sofia Nadira Megat Kamaruddin, Siti Hafizah Zulkiply, Nur Hayati Azizul, Norhayati Mustafa Khalid, Azizan Ali, Izyan Mohd Idris, Yong Shih Mei, Shazana Rifham Abdullah, Norfashihah Faridus, Nur Azirah Md Yusof, Nur Najwa Farahin M Yusoff, Rahman Jamal, Aizai Azan Abdul Rahim, Abdul Kahar Abdul Ghapar, Ammu Kutty Radhakrishnan, Alan Yean Yip Fong, Omar Ismail, Saravanan Krishinan, Chuey Yan Lee, Liew Houng Bang, Eashwary Mageswaren, Kauthaman Mahendran, Nor Hanim Mohd Amin, Gunavathy Muthusamy, Aaron Ong Hean Jin, Ahmad Wazi Ramli, Noel Thomas Ross, Anwar Irawan Ruhani, Mansor Yahya, Yusniza Yusoff, Siti Khairani Zainal Abidin, Laryssa Amado, Thomas Bolton, Sophie Weston, Jason Crawte, Niko Ovenden, Ank Michielsen, Md Mostafa Monower, Wan Rozita Wan Mahiyuddin, Angela Wood, Emanuele Di Angelantonio, Nur Suffia Sulaiman, John Danesh, Adam S Butterworth.
PY - 2022
Y1 - 2022
N2 - Background: Although the burden of premature myocardial infarction (MI) is high in Malaysia, direct evidence on the determinants of MI in this multi-ethnic population remains sparse. Objective: The Malaysian Acute Vascular Events Risk (MAVERIK) study is a retrospective case-control study established to investigate the genomic, lipid-related, and other determinants of acute MI in Malaysia. In this paper, we report the study protocol and early results. Methods: By June 2019, we had enrolled approximately 2500 patients with their first MI and 2500 controls without cardiovascular disease, who were frequency-matched by age, sex, and ethnicity, from 17 hospitals in Malaysia. For each participant, serum and whole blood have been collected and stored. Clinical, demographic, and behavioral information has been obtained using a 200-item questionnaire. Results: Tobacco consumption, a history of diabetes, hypertension, markers of visceral adiposity, indicators of lower socioeconomic status, and a family history of coronary disease were more prevalent in cases than in controls. Adjusted (age and sex) logistic regression models for traditional risk factors indicated that current smoking (odds ratio [OR] 4.11, 95% CI 3.56-4.75; P<.001), previous smoking (OR 1.34, 95% CI 1.12-1.60; P=.001), a history of high blood pressure (OR 2.13, 95% CI 1.86-2.44; P<.001), a history of diabetes mellitus (OR 2.72, 95% CI 2.34-3.17; P<.001), a family history of coronary heart disease (OR 1.28, 95% CI 1.07-1.55; P=.009), and obesity (BMI >30 kg/m2; OR 1.19, 95% CI 1.05-1.34; P=.009) were associated with MI in age- and sex-adjusted models. Conclusions: The MAVERIK study can serve as a useful platform to investigate genetic and other risk factors for MI in an understudied Southeast Asian population. It should help to hasten the discovery of disease-causing pathways and inform regionally appropriate strategies that optimize public health action.
AB - Background: Although the burden of premature myocardial infarction (MI) is high in Malaysia, direct evidence on the determinants of MI in this multi-ethnic population remains sparse. Objective: The Malaysian Acute Vascular Events Risk (MAVERIK) study is a retrospective case-control study established to investigate the genomic, lipid-related, and other determinants of acute MI in Malaysia. In this paper, we report the study protocol and early results. Methods: By June 2019, we had enrolled approximately 2500 patients with their first MI and 2500 controls without cardiovascular disease, who were frequency-matched by age, sex, and ethnicity, from 17 hospitals in Malaysia. For each participant, serum and whole blood have been collected and stored. Clinical, demographic, and behavioral information has been obtained using a 200-item questionnaire. Results: Tobacco consumption, a history of diabetes, hypertension, markers of visceral adiposity, indicators of lower socioeconomic status, and a family history of coronary disease were more prevalent in cases than in controls. Adjusted (age and sex) logistic regression models for traditional risk factors indicated that current smoking (odds ratio [OR] 4.11, 95% CI 3.56-4.75; P<.001), previous smoking (OR 1.34, 95% CI 1.12-1.60; P=.001), a history of high blood pressure (OR 2.13, 95% CI 1.86-2.44; P<.001), a history of diabetes mellitus (OR 2.72, 95% CI 2.34-3.17; P<.001), a family history of coronary heart disease (OR 1.28, 95% CI 1.07-1.55; P=.009), and obesity (BMI >30 kg/m2; OR 1.19, 95% CI 1.05-1.34; P=.009) were associated with MI in age- and sex-adjusted models. Conclusions: The MAVERIK study can serve as a useful platform to investigate genetic and other risk factors for MI in an understudied Southeast Asian population. It should help to hasten the discovery of disease-causing pathways and inform regionally appropriate strategies that optimize public health action.
KW - Cardiovascular disease
KW - Case-control study
KW - Malaysia
KW - Myocardial infarction
UR - http://www.scopus.com/inward/record.url?scp=85124976134&partnerID=8YFLogxK
U2 - 10.2196/31885
DO - 10.2196/31885
M3 - Article
AN - SCOPUS:85124976134
SN - 1929-0748
VL - 11
JO - JMIR Research Protocols
JF - JMIR Research Protocols
IS - 2
M1 - e31885
ER -
