Inverse agonism: A developing concept of drug action

Arthur Christopoulos, Fred Mitchelson

Research output: Contribution to journalArticleResearch


The concept of drugs behaving as either stimulants of receptor systems (agonists) or inhibitors (antagonists) has been the conceptual basis for drug action for many years. Research based on this concept has produced most of the drugs we presently have available to us. This article outlines a new concept which has emerged from recent fundamental research, that of inverse agonism. Only time will tell if new and useful drugs emerge as a result of exploiting this.

Original languageEnglish
Pages (from-to)868-871
Number of pages4
JournalAustralian Journal of Pharmacy
Issue number917
Publication statusPublished - 1 Aug 1996

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