Invasive central nervous system aspergillosis: Cure with liposomal amphotericin b, itraconazole, and radical surgery–case report and review of the literature

Jacinta M. Coleman, Geoff G. Hogg, Jeffrey V. Rosenfeld, Keith D. Waters

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126 Citations (Scopus)

Abstract

INVASIVE ASPERGILLOSIS OF the central nervous system is a rare but well-described disease. There have been only a few reported survivors, and mortality exceeds 95% in the immunosuppressed host. We present a 2-year-old boy with acute lymphatic leukemia and multiple Aspergillus brain abscesses who was successfully treated with liposomal amphotericin B, itraconazole, and surgical excision of the abscesses. Liposomal amphotericin B is a new preparation that safely allows the attainment of significantly higher tissue levels with less toxicity than standard amphotericin B. The treatment of patients with invasive central nervous system aspergillosis is reviewed.

Original languageEnglish
Pages (from-to)858-863
Number of pages6
JournalNeurosurgery
Volume36
Issue number4
DOIs
Publication statusPublished - 1 Jan 1995
Externally publishedYes

Keywords

  • Aspergillus
  • Cerebral abscess
  • Immunosuppression
  • Itraconazole
  • Liposomal amphotericin b
  • Neurosurgery

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