TY - JOUR
T1 - Inulin controls inflammation and metabolic endotoxemia in women with type 2 diabetes mellitus
T2 - A randomized-controlled clinical trial
AU - Dehghan, Parvin
AU - Gargari, Bahram Pourghassem
AU - Jafar-Abadi, Mohammad Asghari
AU - Aliasgharzadeh, Akbar
N1 - Funding Information:
The authors declare no conflict of interests. The authors alone are responsible for the content and writing of this article. This research was financially supported by Health and Nutrition Faculty, Nutrition Research
PY - 2014/2
Y1 - 2014/2
N2 - There is limited evidence on the effects of prebiotics on inflammation. Therefore, the aim of this study was to evaluate the effects of inulin supplementation on inflammatory indices and metabolic endotoxemia in patients with type 2 diabetes mellitus. The participants included diabetic females (n=49). They were divided into an intervention group (n=24) as well as a control group (n=25) and received 10g/d inulin or maltodextrin for 8 weeks, respectively. Fasting blood sugar (FBS), HbA1c, insulin, high-sensitive C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), and plasma lipopolysaccharide (LPS) were measured pre and post intervention. Inulin-supplemented patients exhibited a significant decrease in FBS (8.5%), HbA1c (10.4%), fasting insulin (34.3%), homeostasis model assessment of insulin resistance (HOMA-IR) (39.5%), hs-CRP (35.6%), TNF-α (23.1%), and LPS (27.9%) compared with the maltodextrin group (p<0.05). Increase in IL-10 was not significant in inulin compared with the maltodextrin group. It can be concluded that inulin supplementation seems to be able to modulate inflammation and metabolic endotoxemia in women with type 2 diabetes.
AB - There is limited evidence on the effects of prebiotics on inflammation. Therefore, the aim of this study was to evaluate the effects of inulin supplementation on inflammatory indices and metabolic endotoxemia in patients with type 2 diabetes mellitus. The participants included diabetic females (n=49). They were divided into an intervention group (n=24) as well as a control group (n=25) and received 10g/d inulin or maltodextrin for 8 weeks, respectively. Fasting blood sugar (FBS), HbA1c, insulin, high-sensitive C-reactive protein (hs-CRP), tumor necrosis factor-alpha (TNF-α), interleukin-10 (IL-10), and plasma lipopolysaccharide (LPS) were measured pre and post intervention. Inulin-supplemented patients exhibited a significant decrease in FBS (8.5%), HbA1c (10.4%), fasting insulin (34.3%), homeostasis model assessment of insulin resistance (HOMA-IR) (39.5%), hs-CRP (35.6%), TNF-α (23.1%), and LPS (27.9%) compared with the maltodextrin group (p<0.05). Increase in IL-10 was not significant in inulin compared with the maltodextrin group. It can be concluded that inulin supplementation seems to be able to modulate inflammation and metabolic endotoxemia in women with type 2 diabetes.
KW - Cytokines
KW - Lipopolysaccharide
KW - Prebiotics
UR - http://www.scopus.com/inward/record.url?scp=84892753751&partnerID=8YFLogxK
U2 - 10.3109/09637486.2013.836738
DO - 10.3109/09637486.2013.836738
M3 - Article
C2 - 24059649
AN - SCOPUS:84892753751
SN - 0963-7486
VL - 65
SP - 117
EP - 123
JO - International Journal of Food Sciences and Nutrition
JF - International Journal of Food Sciences and Nutrition
IS - 1
ER -
