Introduction of a mutation in the shutter region of antithrombin (Phe77 Leu) increases affinity for heparin and decreases thermal stability

Noelene S Quinsey; Hazel L Fitton; Paul B Coughlin; James C Whisstock; Timothy R Dafforn; Robin W Carrell; Stephen P Bottomley; Robert N Pike

doi:10.1021/bi0349322

Introduction of a mutation in the shutter region of antithrombin (Phe77 Leu) increases affinity for heparin and decreases thermal stability

Noelene S Quinsey, Hazel L Fitton, Paul B Coughlin, James C Whisstock, Timothy R Dafforn, Robin W Carrell, Stephen P Bottomley, Robert N Pike

Research output: Contribution to journal › Article › Research › peer-review

6 Citations (Scopus)

Original language	English
Pages (from-to)	10169 - 10173
Number of pages	5
Journal	Biochemistry
Volume	42
Issue number	34
DOIs	https://doi.org/10.1021/bi0349322
Publication status	Published - 2003

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10.1021/bi0349322

Cite this

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title = "Introduction of a mutation in the shutter region of antithrombin (Phe77 Leu) increases affinity for heparin and decreases thermal stability",

author = "Quinsey, {Noelene S} and Fitton, {Hazel L} and Coughlin, {Paul B} and Whisstock, {James C} and Dafforn, {Timothy R} and Carrell, {Robin W} and Bottomley, {Stephen P} and Pike, {Robert N}",

year = "2003",

doi = "10.1021/bi0349322",

language = "English",

volume = "42",

pages = "10169 -- 10173",

journal = "Biochemistry",

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publisher = "American Chemical Society",

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T1 - Introduction of a mutation in the shutter region of antithrombin (Phe77 Leu) increases affinity for heparin and decreases thermal stability

AU - Quinsey, Noelene S

AU - Fitton, Hazel L

AU - Coughlin, Paul B

AU - Whisstock, James C

AU - Dafforn, Timothy R

AU - Carrell, Robin W

AU - Bottomley, Stephen P

AU - Pike, Robert N

PY - 2003

Y1 - 2003

U2 - 10.1021/bi0349322

DO - 10.1021/bi0349322

M3 - Article

SN - 0006-2960

VL - 42

SP - 10169

EP - 10173

JO - Biochemistry

JF - Biochemistry

IS - 34

ER -