Susanne Feil, Galina Polekhina, Michael Gorman, Michael Parker

Research output: Chapter in Book/Report/Conference proceedingChapter (Book)Researchpeer-review


Pore-forming proteins (PFPs) possess the intriguing property that they can exist either in a stable water-soluble state or as an integral membrane pore. These molecules can undergo large conformational changes in converting between these two states. Much of what we know about how these proteins change their shape comes from work on bacterial toxins and increasingly, in more recent years, on toxins from other organisms. Surprisingly, a number of pore-forming proteins have recently been characterised that appear to have adopted similar stratagies to toxins for binding and inserting into biological membranes.
Original languageEnglish
Title of host publicationProteins: Membrane Binding and Pore Formation
EditorsGregor Anderluh, Jeremy Lakey
Place of PublicationNew York, United States
Pages1 - 13
Number of pages13
ISBN (Print)9781441963260
Publication statusPublished - 2010

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