Intrinsic connectivity provides the baseline framework for individual variability in motor performance: A multivariate fusion analysis of low- and high-frequency resting-state oscillations and antisaccade performance

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Abstract

Intrinsic brain activity provides the functional framework for the brain's full repertoire of behavioral responses; that is, a common mechanism underlies intrinsic and extrinsic neural activity, with extrinsic activity building upon the underlying baseline intrinsic activity. The generation of a motor movement in response to sensory stimulation is one of the most fundamental functions of the central nervous system. Since saccadic eye movements are among our most stereotyped motor responses, we hypothesized that individual variability in the ability to inhibit a prepotent saccade and make a voluntary antisaccade would be related to individual variability in intrinsic connectivity. Twenty-three individuals completed the antisaccade task and resting-state functional magnetic resonance imaging (fMRI). A multivariate analysis of covariance identified relationships between fMRI oscillations (0.01–0.2 Hz) of resting-state networks determined using high-dimensional independent component analysis and antisaccade performance (latency, error rate). Significant multivariate relationships between antisaccade latency and directional error rate were obtained in independent components across the entire brain. Some of the relationships were obtained in components that overlapped substantially with the task; however, many were obtained in components that showed little overlap with the task. The current results demonstrate that even in the absence of a task, spectral power in regions showing little overlap with task activity predicts an individual's performance on a saccade task.
Original languageEnglish
Pages (from-to)505-517
Number of pages13
JournalBrain Connectivity
Volume6
Issue number6
DOIs
Publication statusPublished - 1 Jul 2016

Keywords

  • antisaccade
  • functional magnetic resonance imaging (fMRI)
  • intrinsic connectivity
  • low-frequency oscillations
  • multivariate covariate analysis
  • oculomotor
  • resting-state fMRI
  • time-course spectra

Cite this

@article{fafbb2f156d14b59a227eb9589ff310c,
title = "Intrinsic connectivity provides the baseline framework for individual variability in motor performance: A multivariate fusion analysis of low- and high-frequency resting-state oscillations and antisaccade performance",
abstract = "Intrinsic brain activity provides the functional framework for the brain's full repertoire of behavioral responses; that is, a common mechanism underlies intrinsic and extrinsic neural activity, with extrinsic activity building upon the underlying baseline intrinsic activity. The generation of a motor movement in response to sensory stimulation is one of the most fundamental functions of the central nervous system. Since saccadic eye movements are among our most stereotyped motor responses, we hypothesized that individual variability in the ability to inhibit a prepotent saccade and make a voluntary antisaccade would be related to individual variability in intrinsic connectivity. Twenty-three individuals completed the antisaccade task and resting-state functional magnetic resonance imaging (fMRI). A multivariate analysis of covariance identified relationships between fMRI oscillations (0.01–0.2 Hz) of resting-state networks determined using high-dimensional independent component analysis and antisaccade performance (latency, error rate). Significant multivariate relationships between antisaccade latency and directional error rate were obtained in independent components across the entire brain. Some of the relationships were obtained in components that overlapped substantially with the task; however, many were obtained in components that showed little overlap with the task. The current results demonstrate that even in the absence of a task, spectral power in regions showing little overlap with task activity predicts an individual's performance on a saccade task.",
keywords = "antisaccade, functional magnetic resonance imaging (fMRI), intrinsic connectivity, low-frequency oscillations, multivariate covariate analysis, oculomotor, resting-state fMRI, time-course spectra",
author = "Jamadar, {Sharna D} and Egan, {Gary F} and Calhoun, {Vince D} and Beth Johnson and Joanne Fielding",
year = "2016",
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doi = "10.1089/brain.2015.0411",
language = "English",
volume = "6",
pages = "505--517",
journal = "Brain Connectivity",
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T1 - Intrinsic connectivity provides the baseline framework for individual variability in motor performance

T2 - A multivariate fusion analysis of low- and high-frequency resting-state oscillations and antisaccade performance

AU - Jamadar, Sharna D

AU - Egan, Gary F

AU - Calhoun, Vince D

AU - Johnson, Beth

AU - Fielding, Joanne

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N2 - Intrinsic brain activity provides the functional framework for the brain's full repertoire of behavioral responses; that is, a common mechanism underlies intrinsic and extrinsic neural activity, with extrinsic activity building upon the underlying baseline intrinsic activity. The generation of a motor movement in response to sensory stimulation is one of the most fundamental functions of the central nervous system. Since saccadic eye movements are among our most stereotyped motor responses, we hypothesized that individual variability in the ability to inhibit a prepotent saccade and make a voluntary antisaccade would be related to individual variability in intrinsic connectivity. Twenty-three individuals completed the antisaccade task and resting-state functional magnetic resonance imaging (fMRI). A multivariate analysis of covariance identified relationships between fMRI oscillations (0.01–0.2 Hz) of resting-state networks determined using high-dimensional independent component analysis and antisaccade performance (latency, error rate). Significant multivariate relationships between antisaccade latency and directional error rate were obtained in independent components across the entire brain. Some of the relationships were obtained in components that overlapped substantially with the task; however, many were obtained in components that showed little overlap with the task. The current results demonstrate that even in the absence of a task, spectral power in regions showing little overlap with task activity predicts an individual's performance on a saccade task.

AB - Intrinsic brain activity provides the functional framework for the brain's full repertoire of behavioral responses; that is, a common mechanism underlies intrinsic and extrinsic neural activity, with extrinsic activity building upon the underlying baseline intrinsic activity. The generation of a motor movement in response to sensory stimulation is one of the most fundamental functions of the central nervous system. Since saccadic eye movements are among our most stereotyped motor responses, we hypothesized that individual variability in the ability to inhibit a prepotent saccade and make a voluntary antisaccade would be related to individual variability in intrinsic connectivity. Twenty-three individuals completed the antisaccade task and resting-state functional magnetic resonance imaging (fMRI). A multivariate analysis of covariance identified relationships between fMRI oscillations (0.01–0.2 Hz) of resting-state networks determined using high-dimensional independent component analysis and antisaccade performance (latency, error rate). Significant multivariate relationships between antisaccade latency and directional error rate were obtained in independent components across the entire brain. Some of the relationships were obtained in components that overlapped substantially with the task; however, many were obtained in components that showed little overlap with the task. The current results demonstrate that even in the absence of a task, spectral power in regions showing little overlap with task activity predicts an individual's performance on a saccade task.

KW - antisaccade

KW - functional magnetic resonance imaging (fMRI)

KW - intrinsic connectivity

KW - low-frequency oscillations

KW - multivariate covariate analysis

KW - oculomotor

KW - resting-state fMRI

KW - time-course spectra

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