Abstract
| Original language | English |
|---|---|
| Pages (from-to) | 2127 - 2137 |
| Number of pages | 11 |
| Journal | The Journal of Physiology |
| Volume | 591 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2013 |
Cite this
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Intrauterine inflammation alters cardiopulmonary and cerebral haemodynamics at birth in preterm lambs. / Galinsky, Robert; Hooper, Stuart Brian; Wallace, Megan Jane; Westover, Alana Jasmine; Black, Mary Jane; Moss, Timothy James Murugesan; Polglase, Graeme.
In: The Journal of Physiology, Vol. 591, No. 8, 2013, p. 2127 - 2137.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Intrauterine inflammation alters cardiopulmonary and cerebral haemodynamics at birth in preterm lambs
AU - Galinsky, Robert
AU - Hooper, Stuart Brian
AU - Wallace, Megan Jane
AU - Westover, Alana Jasmine
AU - Black, Mary Jane
AU - Moss, Timothy James Murugesan
AU - Polglase, Graeme
PY - 2013
Y1 - 2013
N2 - Intrauterine inflammation is associated with preterm birth and poor long-term cardiopulmonary outcomes. We aimed to determine the effect of intrauterine inflammation on the cardiopulmonary and cerebral haemodynamic transition at birth, and the response to subsequent haemodynamic challenge. Fetal instrumentation was performed at approximately 112 days gestation (term is 147 days) for measurement of cardiopulmonary and cerebral haemodynamics. At 118 days, inflammation was induced by intra-amniotic administration of lipopolysaccharide (LPS; n = 7); controls (n = 5) received intra-amniotic saline. At 125 days lambs were delivered and mechanically ventilated. Arterial blood gases, pulmonary and systemic arterial blood pressures and flows were measured during the perinatal period. At 10 min a haemodynamic challenge was administered by increasing positive end-expiratory pressure. During the first 10 min after birth, LPS-exposed lambs had higher pulmonary vascular resistance and lower pulmonary blood flow and left ventricular output than controls. Carotid arterial blood flow was higher in LPS-exposed lambs than controls between 3 and 7 min after delivery, and cerebral oxygen delivery was higher at 5 min. During the haemodynamic challenge, pulmonary blood flow and left ventricular output were reduced in controls but not in LPS-exposed lambs; a transient reduction in brachiocephalic arterial pressure occurred in LPS-exposed lambs but not in controls. Intrauterine inflammation altered the cardiopulmonary and cerebral haemodynamic transition at birth and reduced the cardiopulmonary response to a haemodynamic challenge after birth. The transient reduction in brachiocephalic arterial pressure suggests intrauterine inflammation may alter cerebrovascular control following an increase in positive end-expiratory pressure.
AB - Intrauterine inflammation is associated with preterm birth and poor long-term cardiopulmonary outcomes. We aimed to determine the effect of intrauterine inflammation on the cardiopulmonary and cerebral haemodynamic transition at birth, and the response to subsequent haemodynamic challenge. Fetal instrumentation was performed at approximately 112 days gestation (term is 147 days) for measurement of cardiopulmonary and cerebral haemodynamics. At 118 days, inflammation was induced by intra-amniotic administration of lipopolysaccharide (LPS; n = 7); controls (n = 5) received intra-amniotic saline. At 125 days lambs were delivered and mechanically ventilated. Arterial blood gases, pulmonary and systemic arterial blood pressures and flows were measured during the perinatal period. At 10 min a haemodynamic challenge was administered by increasing positive end-expiratory pressure. During the first 10 min after birth, LPS-exposed lambs had higher pulmonary vascular resistance and lower pulmonary blood flow and left ventricular output than controls. Carotid arterial blood flow was higher in LPS-exposed lambs than controls between 3 and 7 min after delivery, and cerebral oxygen delivery was higher at 5 min. During the haemodynamic challenge, pulmonary blood flow and left ventricular output were reduced in controls but not in LPS-exposed lambs; a transient reduction in brachiocephalic arterial pressure occurred in LPS-exposed lambs but not in controls. Intrauterine inflammation altered the cardiopulmonary and cerebral haemodynamic transition at birth and reduced the cardiopulmonary response to a haemodynamic challenge after birth. The transient reduction in brachiocephalic arterial pressure suggests intrauterine inflammation may alter cerebrovascular control following an increase in positive end-expiratory pressure.
UR - http://jp.physoc.org/content/591/8/2127.full.pdf+html
U2 - 10.1113/jphysiol.2012.249680
DO - 10.1113/jphysiol.2012.249680
M3 - Article
VL - 591
SP - 2127
EP - 2137
JO - The Journal of Physiology
JF - The Journal of Physiology
SN - 0022-3751
IS - 8
ER -