Intrauterine growth restriction affects the maturation of myelin

Mary Tolcos, Elizabeth Bateman, Rachel O'Dowd, Rachel Markwick, Krijn Vrijsen, Alexandra Rehn, Sandra Rees

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Abstract

Intrauterine growth-restriction (IUGR) can lead to adverse neurodevelopmental sequelae in postnatal life. Our objective was to determine whether IUGR, induced by chronic placental insufficiency (CPI) in the guinea pig results in long-term deficits in brain myelination and could therefore contribute to altered neural function. CPI was induced by unilateral ligation of the uterine artery at mid-gestation (term 67 days of gestation; dg), producing growth-restricted (GR) foetuses (60 dg), neonates (1 week) and young adults (8 week); controls were from the unligated horn or sham-operated animals. In GR foetuses (n=8) and neonates (n=7), white matter (WM) volume was reduced (p
Original languageEnglish
Pages (from-to)53 - 65
Number of pages13
JournalExperimental Neurology
Volume232
Issue number1
DOIs
Publication statusPublished - 2011

Cite this

Tolcos, M., Bateman, E., O'Dowd, R., Markwick, R., Vrijsen, K., Rehn, A., & Rees, S. (2011). Intrauterine growth restriction affects the maturation of myelin. Experimental Neurology, 232(1), 53 - 65. https://doi.org/10.1016/j.expneurol.2011.08.002