Intrathymic programming of effector fates in three molecularly distinct gammadelta T cell subtypes

Kavitha Narayan, Katelyn Sylvia, Nidhi Malhotra, Catherine C Yin, Gregory Martens, Therese Vallerskog, Hardy Kornfeld, Na Xiong, Nadia R Cohen, Michael B Brenner, Leslie J Berg, Joonsoo Kang, Yan Zhou, Sara Shinton, Richard R Hardy, Natalie A Bezman, Joseph C Sun, Charles C Kim, Lewis L Lanier, Jennifer C MillerBrian D Brown, Miriam Merad, Anne Louise Fletcher, Kutlu G Elpek, Angelique Bellemare-Pelletier, Deepali Malhotra, Shannon J Turley, Roi Gazit, Brian S Garrison, Derrick J Rossi, Vladimir Jojic, Daphne Koller, Radu Jianu, David H Laidlaw, James C Costello, James J Collins, Patrick Joseph Brennan, Tal Shay, Aviv Regev, Francis S Kim, Tata Nageswara Rao, Amy Wagers, Emmanuel L Gautier, Claudia V Jakubzick, Gwendalyn L Randolph, Paul Monach, Adam J Best, Jamie Knell, Ananda W Goldrath, Tracy Shu Ping Heng, Taras Kreslavsky, Michio W Painter, Diane Mathis, Christophe Benoist

Research output: Contribution to journalArticleResearchpeer-review

167 Citations (Scopus)


Innate gammadelta T cells function in the early phase of immune responses. Although innate gammadelta T cells have often been studied as one homogenous population, they can be functionally classified into effector subsets on the basis of the production of signature cytokines, analogous to adaptive helper T cell subsets. However, unlike the function of adaptive T cells, gammadelta effector T cell function correlates with genomically encoded T cell antigen receptor (TCR) chains, which suggests that clonal TCR selection is not the main determinant of the differentiation of gammadelta effector cells. A high-resolution transcriptome analysis of all emergent gammadelta thymocyte subsets segregated on the basis of use of the TCR gamma-chain or delta-chain indicated the existence of three separate subtypes of gammadelta effector cells in the thymus. The immature gammadelta subsets were distinguished by unique transcription-factor modules that program effector function.
Original languageEnglish
Pages (from-to)511 - 518
Number of pages8
JournalNature Immunology
Issue number5
Publication statusPublished - 2012
Externally publishedYes

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