Intrathecal administration of neutralizing antibody against Fas ligand suppresses the progression of experimental autoimmune encephalomyelitis

Yoshinobu Okuda, Saburo Sakoda, Harutoshi Fujimura, Shigekazu Nagata, Takehiko Yanagihara, Claude C.A. Bernard

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Abstract

A therapy aimed a blocking the Fas/Fas ligand (FasL) system was investigated using a relapsing form of experimental autoimmune encephalomyelitis (EAE) in mice, an animal model of multiple sclerosis (MS). Intracisternal administration of neutralizing antibody against FasL during the progression phase of EAE significantly reduced the severity of the disease with milder inflammation and myelin breakdown in the central nervous system (CNS). These results raised the possibility that the Fas/FasL system might contribute to tissue destruction in the CNS in the acute phase of EAE and that the intrathecal administration of neutralizing antibody against FasL may be beneficial for suppression of the acute phase of MS. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)164-168
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume275
Issue number1
DOIs
Publication statusPublished - 18 Aug 2000
Externally publishedYes

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