Intraperitoneal medetomidine: a novel analgesic strategy for postoperative pain management in pregnant sheep

F R Murdoch, G L Maker, Ilias Nitsos, Graeme Polglase, Gabrielle C Musk

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14 Citations (Scopus)


The absorption of medetomidine released by continuous infusion from an osmotic pump in the abdominal cavity was studied in pregnant sheep during the 24 h postoperative period. Additionally pain and sedation was assessed. Eleven sheep were studied: six were treated with a medetomidine loaded osmotic pump delivering 10 microL/h (3 microg/kg/h medetomidine); and five with a saline loaded osmotic pump (control). Serial blood samples were taken and analysed to determine plasma medetomidine levels. Medetomidine was absorbed from the peritoneal cavity and a steady plasma concentration was achieved within 10 h, mean (SD) peak concentration was 2.87 (0.22) ng/mL. Sheep receiving medetomidine analgesia had significantly lower pain scores at 10 h than controls. Four control sheep required rescue analgesia, compared with 0 in the treatment group. Delivery of 3 microg/kg/h medetomidine by an intraperitoneal osmotic pump to pregnant sheep in the 24 h postoperative period provides adequate plasma concentrations of medetomidine for analgesia without sedation.
Original languageEnglish
Pages (from-to)66 - 70
Number of pages5
JournalLaboratory Animals
Issue number1
Publication statusPublished - 2013

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