TY - JOUR
T1 - Intracrine oestrogen production and action in breast cancer: an epigenetic focus
AU - Knower, Kevin Christopher
AU - To, Sarah Quynh Giao
AU - Clyne, Colin
PY - 2013
Y1 - 2013
N2 - Epigenome changes have been widely demonstrated to contribute to the initiation and progression of a vast array of cancers including breast cancer. The reversible process of many epigenetic modifications is thus an attractive feature for the development of novel therapeutic measures. In oestrogen receptor alpha (hereinafter referred to as ER) positive tumours, endocrine therapies have proven beneficial in patient care, particularly in postmenopausal women where two-thirds of tumours are oestrogen dependent. However, resistance to such therapies is a common feature amongst individuals. In the current review, we discuss the influence that epigenetics has on oestrogen dependent breast cancers, in particular (i) the production of intracrine oestrogen in postmenopausal women, (ii) the action of oestrogen on epigenetic processes, and (iii) the links between epigenetics and endocrine resistance and the current advancements in epigenetic therapy that target this process. This article is part of a Special Issue entitled CSR 2013 .
AB - Epigenome changes have been widely demonstrated to contribute to the initiation and progression of a vast array of cancers including breast cancer. The reversible process of many epigenetic modifications is thus an attractive feature for the development of novel therapeutic measures. In oestrogen receptor alpha (hereinafter referred to as ER) positive tumours, endocrine therapies have proven beneficial in patient care, particularly in postmenopausal women where two-thirds of tumours are oestrogen dependent. However, resistance to such therapies is a common feature amongst individuals. In the current review, we discuss the influence that epigenetics has on oestrogen dependent breast cancers, in particular (i) the production of intracrine oestrogen in postmenopausal women, (ii) the action of oestrogen on epigenetic processes, and (iii) the links between epigenetics and endocrine resistance and the current advancements in epigenetic therapy that target this process. This article is part of a Special Issue entitled CSR 2013 .
KW - Epigenetics
KW - Oestrogen biosynthesis
KW - Postmenopausal breast cance
KW - Endocrine therapy
KW - Aromatase
KW - DNA methylation
UR - http://www.sciencedirect.com/science/article/pii/S0960076013000149
U2 - 10.1016/j.jsbmb.2013.01.009
DO - 10.1016/j.jsbmb.2013.01.009
M3 - Article
SN - 0960-0760
VL - 137
SP - 157
EP - 164
JO - The Journal of Steroid Biochemistry and Molecular Biology
JF - The Journal of Steroid Biochemistry and Molecular Biology
ER -