Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: Further development of a rodent model of autism

Sandy R. Shultz; Derrick F. MacFabe; Samantha Martin; Jordana Jackson; Roy Taylor; Francis Boon; Klaus Peter Ossenkopp; Donald P. Cain

doi:10.1016/j.bbr.2008.12.023

Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: Further development of a rodent model of autism

Sandy R. Shultz, Derrick F. MacFabe, Samantha Martin, Jordana Jackson, Roy Taylor, Francis Boon, Klaus Peter Ossenkopp, Donald P. Cain

Research output: Contribution to journal › Article › Research › peer-review

90 Citations (Scopus)

Abstract

Propionic acid (PPA) is a dietary short chain fatty acid and a metabolic end-product of enteric bacteria. Intracerebroventricular (ICV) injections of PPA can result in brain and behavioral abnormalities in rats similar to those seen in humans suffering from autism. To evaluate cognition and sensorimotor ability in the PPA model, male Long-Evans hooded rats received ICV injection of PPA or control compounds prior to behavioral testing in water maze and beam tasks. Compared to controls, PPA-treated rats were impaired in the water maze task as indicated by an unusual pattern of mild or no impairment during spatial acquisition training, but marked impairment during spatial reversal training. PPA-treated rats were also impaired on the beam task. Neuropathological analysis from PPA-treated rats revealed an innate neuroinflammatory response. These findings add to evidence that PPA can change the brain and behavior in the laboratory rat consistent with symptoms of human autism. Crown

Original language	English
Pages (from-to)	33-41
Number of pages	9
Journal	Behavioural Brain Research
Volume	200
Issue number	1
DOIs	https://doi.org/10.1016/j.bbr.2008.12.023
Publication status	Published - 8 Jun 2009
Externally published	Yes

Keywords

Animal model
Autism spectrum disorders
Clostridia
Neuroinflammation
Perseveration
Sensorimotor
Short chain fatty acids
Spatial cognition

Access to Document

10.1016/j.bbr.2008.12.023

Cite this

Shultz, S. R., MacFabe, D. F., Martin, S., Jackson, J., Taylor, R., Boon, F., Ossenkopp, K. P., & Cain, D. P. (2009). Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: Further development of a rodent model of autism. Behavioural Brain Research, 200(1), 33-41. https://doi.org/10.1016/j.bbr.2008.12.023

@article{1196e6e57658450c9754397b8a8b9dfa,

title = "Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: Further development of a rodent model of autism",

abstract = "Propionic acid (PPA) is a dietary short chain fatty acid and a metabolic end-product of enteric bacteria. Intracerebroventricular (ICV) injections of PPA can result in brain and behavioral abnormalities in rats similar to those seen in humans suffering from autism. To evaluate cognition and sensorimotor ability in the PPA model, male Long-Evans hooded rats received ICV injection of PPA or control compounds prior to behavioral testing in water maze and beam tasks. Compared to controls, PPA-treated rats were impaired in the water maze task as indicated by an unusual pattern of mild or no impairment during spatial acquisition training, but marked impairment during spatial reversal training. PPA-treated rats were also impaired on the beam task. Neuropathological analysis from PPA-treated rats revealed an innate neuroinflammatory response. These findings add to evidence that PPA can change the brain and behavior in the laboratory rat consistent with symptoms of human autism. Crown",

keywords = "Animal model, Autism spectrum disorders, Clostridia, Neuroinflammation, Perseveration, Sensorimotor, Short chain fatty acids, Spatial cognition",

author = "Shultz, {Sandy R.} and MacFabe, {Derrick F.} and Samantha Martin and Jordana Jackson and Roy Taylor and Francis Boon and Ossenkopp, {Klaus Peter} and Cain, {Donald P.}",

year = "2009",

month = jun,

day = "8",

doi = "10.1016/j.bbr.2008.12.023",

language = "English",

volume = "200",

pages = "33--41",

journal = "Behavioural Brain Research",

issn = "0166-4328",

publisher = "Elsevier BV",

number = "1",

}

Shultz, SR, MacFabe, DF, Martin, S, Jackson, J, Taylor, R, Boon, F, Ossenkopp, KP & Cain, DP 2009, 'Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: Further development of a rodent model of autism', Behavioural Brain Research, vol. 200, no. 1, pp. 33-41. https://doi.org/10.1016/j.bbr.2008.12.023

Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat : Further development of a rodent model of autism. / Shultz, Sandy R.; MacFabe, Derrick F.; Martin, Samantha et al.

In: Behavioural Brain Research, Vol. 200, No. 1, 08.06.2009, p. 33-41.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat

T2 - Further development of a rodent model of autism

AU - Shultz, Sandy R.

AU - MacFabe, Derrick F.

AU - Martin, Samantha

AU - Jackson, Jordana

AU - Taylor, Roy

AU - Boon, Francis

AU - Ossenkopp, Klaus Peter

AU - Cain, Donald P.

PY - 2009/6/8

Y1 - 2009/6/8

N2 - Propionic acid (PPA) is a dietary short chain fatty acid and a metabolic end-product of enteric bacteria. Intracerebroventricular (ICV) injections of PPA can result in brain and behavioral abnormalities in rats similar to those seen in humans suffering from autism. To evaluate cognition and sensorimotor ability in the PPA model, male Long-Evans hooded rats received ICV injection of PPA or control compounds prior to behavioral testing in water maze and beam tasks. Compared to controls, PPA-treated rats were impaired in the water maze task as indicated by an unusual pattern of mild or no impairment during spatial acquisition training, but marked impairment during spatial reversal training. PPA-treated rats were also impaired on the beam task. Neuropathological analysis from PPA-treated rats revealed an innate neuroinflammatory response. These findings add to evidence that PPA can change the brain and behavior in the laboratory rat consistent with symptoms of human autism. Crown

AB - Propionic acid (PPA) is a dietary short chain fatty acid and a metabolic end-product of enteric bacteria. Intracerebroventricular (ICV) injections of PPA can result in brain and behavioral abnormalities in rats similar to those seen in humans suffering from autism. To evaluate cognition and sensorimotor ability in the PPA model, male Long-Evans hooded rats received ICV injection of PPA or control compounds prior to behavioral testing in water maze and beam tasks. Compared to controls, PPA-treated rats were impaired in the water maze task as indicated by an unusual pattern of mild or no impairment during spatial acquisition training, but marked impairment during spatial reversal training. PPA-treated rats were also impaired on the beam task. Neuropathological analysis from PPA-treated rats revealed an innate neuroinflammatory response. These findings add to evidence that PPA can change the brain and behavior in the laboratory rat consistent with symptoms of human autism. Crown

KW - Animal model

KW - Autism spectrum disorders

KW - Clostridia

KW - Neuroinflammation

KW - Perseveration

KW - Sensorimotor

KW - Short chain fatty acids

KW - Spatial cognition

UR - http://www.scopus.com/inward/record.url?scp=62649112890&partnerID=8YFLogxK

U2 - 10.1016/j.bbr.2008.12.023

DO - 10.1016/j.bbr.2008.12.023

M3 - Article

C2 - 19154758

AN - SCOPUS:62649112890

VL - 200

SP - 33

EP - 41

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

IS - 1

ER -

Intracerebroventricular injections of the enteric bacterial metabolic product propionic acid impair cognition and sensorimotor ability in the Long-Evans rat: Further development of a rodent model of autism

Abstract

Keywords

Access to Document

Other files and links

Cite this