Abstract
Intracerebroventricular (i.c.v.) administration of the β3-AR agonist BRL37344 causes dose dependent decreases in food intake in rats suggesting a role for β3-AR in the central control of feeding. We have conducted experiments investigating the effects of i.c.v. administration of the selective β3-AR agonist CL316243 on Fos expression to determine whether β3-AR stimulation affects neurones within specific brain nuclei. Significantly higher numbers of Fos positive cells were found in the rats treated i.c.v. with CL316243 compared with control rats in the paraventricular hypothalamus, lateral hypothalamic area, ventromedial hypothalamic nucleus and dorsal hypothalamic area. Pre-treatment with the selective β3-AR antagonist SR59230A resulted in a significant decrease in the number of Fos positive cells in all those areas compared with rats treated with CL316243 alone. These experiments demonstrate that i.c.v. administration of selective β3-AR agonist causes neuronal activation in hypothalamic areas important in the central regulation of appetite via a β3-AR mediated effect. (C) 2000 Elsevier Science Ireland Ltd.
| Original language | English |
|---|---|
| Pages (from-to) | 161-164 |
| Number of pages | 4 |
| Journal | Neuroscience Letters |
| Volume | 290 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - 1 Sep 2000 |
Keywords
- Adrenergic
- Brain, Fos
- Immunohistochemistry
- Rat
- β-Adrenoceptor
Cite this
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Intracerebroventricular administration of the β3-adrenoceptor agonist CL 316243 causes Fos immunoreactivity in discrete regions of rat hypothalamus. / Castillo-Meléndez, Margie; McKinley, Michael J.; Summers, Roger J.
In: Neuroscience Letters, Vol. 290, No. 3, 01.09.2000, p. 161-164.Research output: Contribution to journal › Article › Research › peer-review
TY - JOUR
T1 - Intracerebroventricular administration of the β3-adrenoceptor agonist CL 316243 causes Fos immunoreactivity in discrete regions of rat hypothalamus
AU - Castillo-Meléndez, Margie
AU - McKinley, Michael J.
AU - Summers, Roger J.
PY - 2000/9/1
Y1 - 2000/9/1
N2 - Intracerebroventricular (i.c.v.) administration of the β3-AR agonist BRL37344 causes dose dependent decreases in food intake in rats suggesting a role for β3-AR in the central control of feeding. We have conducted experiments investigating the effects of i.c.v. administration of the selective β3-AR agonist CL316243 on Fos expression to determine whether β3-AR stimulation affects neurones within specific brain nuclei. Significantly higher numbers of Fos positive cells were found in the rats treated i.c.v. with CL316243 compared with control rats in the paraventricular hypothalamus, lateral hypothalamic area, ventromedial hypothalamic nucleus and dorsal hypothalamic area. Pre-treatment with the selective β3-AR antagonist SR59230A resulted in a significant decrease in the number of Fos positive cells in all those areas compared with rats treated with CL316243 alone. These experiments demonstrate that i.c.v. administration of selective β3-AR agonist causes neuronal activation in hypothalamic areas important in the central regulation of appetite via a β3-AR mediated effect. (C) 2000 Elsevier Science Ireland Ltd.
AB - Intracerebroventricular (i.c.v.) administration of the β3-AR agonist BRL37344 causes dose dependent decreases in food intake in rats suggesting a role for β3-AR in the central control of feeding. We have conducted experiments investigating the effects of i.c.v. administration of the selective β3-AR agonist CL316243 on Fos expression to determine whether β3-AR stimulation affects neurones within specific brain nuclei. Significantly higher numbers of Fos positive cells were found in the rats treated i.c.v. with CL316243 compared with control rats in the paraventricular hypothalamus, lateral hypothalamic area, ventromedial hypothalamic nucleus and dorsal hypothalamic area. Pre-treatment with the selective β3-AR antagonist SR59230A resulted in a significant decrease in the number of Fos positive cells in all those areas compared with rats treated with CL316243 alone. These experiments demonstrate that i.c.v. administration of selective β3-AR agonist causes neuronal activation in hypothalamic areas important in the central regulation of appetite via a β3-AR mediated effect. (C) 2000 Elsevier Science Ireland Ltd.
KW - Adrenergic
KW - Brain, Fos
KW - Immunohistochemistry
KW - Rat
KW - β-Adrenoceptor
UR - http://www.scopus.com/inward/record.url?scp=0343443088&partnerID=8YFLogxK
U2 - 10.1016/S0304-3940(00)01359-8
DO - 10.1016/S0304-3940(00)01359-8
M3 - Article
VL - 290
SP - 161
EP - 164
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 3
ER -