Projects per year
Throughout pregnancy, the muscle of the uterus (the myometrium) must remain quiescent, permitting normal fetal development. Then, at term, strong coordinated contractions are required in order to achieve expeditious vaginal delivery. These two extremes, quiescence versus forceful contractions, are achieved as a result of exquisite timing of regulatory signalling cascades that control the levels of cytoplasmic calcium which is essential for contraction and as a second messenger, influencing activity of ion channels and cell signalling processes. Intracellular organelles, in particular, the endoplasmic reticulum (ER), mitochondria and caveolae, play a pivotal role in determining the availability of free cytoplasmic calcium in the myometrium.
- 1 Finished
Failure-to-progress in human labour results from a profound electrical negativity of the uterine cells: Targeting the ion channels involved
Parkington, H. & Brennecke, S. P.
1/01/17 → 31/12/21