Intracellular organelles; key regulators of myometrial activity

Helena C Parkington, Edirisinghe R Siriwardhana, Harold A Coleman

Research output: Contribution to journalReview ArticleResearchpeer-review


Throughout pregnancy, the muscle of the uterus (the myometrium) must remain quiescent, permitting normal fetal development. Then, at term, strong coordinated contractions are required in order to achieve expeditious vaginal delivery. These two extremes, quiescence versus forceful contractions, are achieved as a result of exquisite timing of regulatory signalling cascades that control the levels of cytoplasmic calcium which is essential for contraction and as a second messenger, influencing activity of ion channels and cell signalling processes. Intracellular organelles, in particular, the endoplasmic reticulum (ER), mitochondria and caveolae, play a pivotal role in determining the availability of free cytoplasmic calcium in the myometrium.

Original languageEnglish
Pages (from-to)55-61
Number of pages7
JournalCurrent Opinion in Physiology
Publication statusPublished - Feb 2020

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