Intracellular organelles; key regulators of myometrial activity

Helena C Parkington; Edirisinghe R Siriwardhana; Harold A Coleman

doi:10.1016/j.cophys.2019.10.007

Intracellular organelles; key regulators of myometrial activity

Helena C Parkington, Edirisinghe R Siriwardhana, Harold A Coleman

Research output: Contribution to journal › Review Article › Research › peer-review

Abstract

Throughout pregnancy, the muscle of the uterus (the myometrium) must remain quiescent, permitting normal fetal development. Then, at term, strong coordinated contractions are required in order to achieve expeditious vaginal delivery. These two extremes, quiescence versus forceful contractions, are achieved as a result of exquisite timing of regulatory signalling cascades that control the levels of cytoplasmic calcium which is essential for contraction and as a second messenger, influencing activity of ion channels and cell signalling processes. Intracellular organelles, in particular, the endoplasmic reticulum (ER), mitochondria and caveolae, play a pivotal role in determining the availability of free cytoplasmic calcium in the myometrium.

Original language	English
Pages (from-to)	55-61
Number of pages	7
Journal	Current Opinion in Physiology
Volume	13
DOIs	https://doi.org/10.1016/j.cophys.2019.10.007
Publication status	Published - Feb 2020

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10.1016/j.cophys.2019.10.007

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abstract = "Throughout pregnancy, the muscle of the uterus (the myometrium) must remain quiescent, permitting normal fetal development. Then, at term, strong coordinated contractions are required in order to achieve expeditious vaginal delivery. These two extremes, quiescence versus forceful contractions, are achieved as a result of exquisite timing of regulatory signalling cascades that control the levels of cytoplasmic calcium which is essential for contraction and as a second messenger, influencing activity of ion channels and cell signalling processes. Intracellular organelles, in particular, the endoplasmic reticulum (ER), mitochondria and caveolae, play a pivotal role in determining the availability of free cytoplasmic calcium in the myometrium.",

author = "Parkington, {Helena C} and Siriwardhana, {Edirisinghe R} and Coleman, {Harold A}",

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AU - Siriwardhana, Edirisinghe R

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N2 - Throughout pregnancy, the muscle of the uterus (the myometrium) must remain quiescent, permitting normal fetal development. Then, at term, strong coordinated contractions are required in order to achieve expeditious vaginal delivery. These two extremes, quiescence versus forceful contractions, are achieved as a result of exquisite timing of regulatory signalling cascades that control the levels of cytoplasmic calcium which is essential for contraction and as a second messenger, influencing activity of ion channels and cell signalling processes. Intracellular organelles, in particular, the endoplasmic reticulum (ER), mitochondria and caveolae, play a pivotal role in determining the availability of free cytoplasmic calcium in the myometrium.

AB - Throughout pregnancy, the muscle of the uterus (the myometrium) must remain quiescent, permitting normal fetal development. Then, at term, strong coordinated contractions are required in order to achieve expeditious vaginal delivery. These two extremes, quiescence versus forceful contractions, are achieved as a result of exquisite timing of regulatory signalling cascades that control the levels of cytoplasmic calcium which is essential for contraction and as a second messenger, influencing activity of ion channels and cell signalling processes. Intracellular organelles, in particular, the endoplasmic reticulum (ER), mitochondria and caveolae, play a pivotal role in determining the availability of free cytoplasmic calcium in the myometrium.

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JO - Current Opinion in Physiology

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ER -

Intracellular organelles; key regulators of myometrial activity

Abstract

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Failure-to-progress in human labour results from a profound electrical negativity of the uterine cells: Targeting the ion channels involved

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Intracellular organelles; key regulators of myometrial activity

Abstract

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Failure-to-progress in human labour results from a profound electrical negativity of the uterine cells: Targeting the ion channels involved

Cite this