Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

Hien Thi Thu Duong; Zulkamal M Kamarudin; Rafael B Erlich; Yang Li; Mathew W Jones; Maria Kavallaris; Cyrille Boyer; Thomas Paul Davis

doi:10.1039/c2cc37181b

Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

Hien Thi Thu Duong, Zulkamal M Kamarudin, Rafael B Erlich, Yang Li, Mathew W Jones, Maria Kavallaris, Cyrille Boyer, Thomas Paul Davis

Research output: Contribution to journal › Article › Research › peer-review

115 Citations (Scopus)

Abstract

The encapsulation of S-nitrosoglutathione into polymeric nanoparticles substantially improves NO stability in aqueous media without affecting the efficacy of intracellular delivery. The combination of nano-NO delivery and chemotherapy has been found to enhance antitumour activity of chemotherapeutics, as demonstrated using preliminary in vitro experiments with neuroblastoma cells.

Original language	English
Pages (from-to)	4190 - 4192
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	39
DOIs	https://doi.org/10.1039/c2cc37181b
Publication status	Published - 2013
Externally published	Yes

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10.1039/c2cc37181b

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title = "Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers",

abstract = "The encapsulation of S-nitrosoglutathione into polymeric nanoparticles substantially improves NO stability in aqueous media without affecting the efficacy of intracellular delivery. The combination of nano-NO delivery and chemotherapy has been found to enhance antitumour activity of chemotherapeutics, as demonstrated using preliminary in vitro experiments with neuroblastoma cells.",

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AU - Duong, Hien Thi Thu

AU - Kamarudin, Zulkamal M

AU - Erlich, Rafael B

AU - Li, Yang

AU - Jones, Mathew W

AU - Kavallaris, Maria

AU - Boyer, Cyrille

AU - Davis, Thomas Paul

PY - 2013

Y1 - 2013

N2 - The encapsulation of S-nitrosoglutathione into polymeric nanoparticles substantially improves NO stability in aqueous media without affecting the efficacy of intracellular delivery. The combination of nano-NO delivery and chemotherapy has been found to enhance antitumour activity of chemotherapeutics, as demonstrated using preliminary in vitro experiments with neuroblastoma cells.

AB - The encapsulation of S-nitrosoglutathione into polymeric nanoparticles substantially improves NO stability in aqueous media without affecting the efficacy of intracellular delivery. The combination of nano-NO delivery and chemotherapy has been found to enhance antitumour activity of chemotherapeutics, as demonstrated using preliminary in vitro experiments with neuroblastoma cells.

UR - http://pubs.rsc.org/en/content/articlepdf/2013/cc/c2cc37181b

U2 - 10.1039/c2cc37181b

DO - 10.1039/c2cc37181b

M3 - Article

VL - 49

SP - 4190

EP - 4192

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 39

ER -

Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

Abstract

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