Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

Hien Thi Thu Duong, Zulkamal M Kamarudin, Rafael B Erlich, Yang Li, Mathew W Jones, Maria Kavallaris, Cyrille Boyer, Thomas Paul Davis

Research output: Contribution to journalArticleResearchpeer-review

95 Citations (Scopus)

Abstract

The encapsulation of S-nitrosoglutathione into polymeric nanoparticles substantially improves NO stability in aqueous media without affecting the efficacy of intracellular delivery. The combination of nano-NO delivery and chemotherapy has been found to enhance antitumour activity of chemotherapeutics, as demonstrated using preliminary in vitro experiments with neuroblastoma cells.
Original languageEnglish
Pages (from-to)4190 - 4192
Number of pages3
JournalChemical Communications
Volume49
Issue number39
DOIs
Publication statusPublished - 2013
Externally publishedYes

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