The encapsulation of S-nitrosoglutathione into polymeric nanoparticles substantially improves NO stability in aqueous media without affecting the efficacy of intracellular delivery. The combination of nano-NO delivery and chemotherapy has been found to enhance antitumour activity of chemotherapeutics, as demonstrated using preliminary in vitro experiments with neuroblastoma cells.
Duong, H. T. T., Kamarudin, Z. M., Erlich, R. B., Li, Y., Jones, M. W., Kavallaris, M., Boyer, C., & Davis, T. P. (2013). Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers. Chemical Communications, 49(39), 4190 - 4192. https://doi.org/10.1039/c2cc37181b