Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers

Hien Thi Thu Duong, Zulkamal M Kamarudin, Rafael B Erlich, Yang Li, Mathew W Jones, Maria Kavallaris, Cyrille Boyer, Thomas Paul Davis

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81 Citations (Scopus)

Abstract

The encapsulation of S-nitrosoglutathione into polymeric nanoparticles substantially improves NO stability in aqueous media without affecting the efficacy of intracellular delivery. The combination of nano-NO delivery and chemotherapy has been found to enhance antitumour activity of chemotherapeutics, as demonstrated using preliminary in vitro experiments with neuroblastoma cells.
Original languageEnglish
Pages (from-to)4190 - 4192
Number of pages3
JournalChemical Communications
Volume49
Issue number39
DOIs
Publication statusPublished - 2013
Externally publishedYes

Cite this

Duong, H. T. T., Kamarudin, Z. M., Erlich, R. B., Li, Y., Jones, M. W., Kavallaris, M., Boyer, C., & Davis, T. P. (2013). Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers. Chemical Communications, 49(39), 4190 - 4192. https://doi.org/10.1039/c2cc37181b