Intra-islet proliferation of cytotoxic T lymphocytes contributes to insulitis progression

Kate L Graham, Balasubramanian Krishnamurthy, Stacey Fynch, Rochelle Ayala-Perez, Robyn Maree Slattery, Pere Santamaria, Helen E Thomas, Thomas W H Kay

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30 Citations (Scopus)


Infiltration of pancreatic islets by immune cells, termed insulitis, increases progressively once it begins and leads to clinical type 1 diabetes. But even after diagnosis some islets remain unaffected and infiltration is patchy rather than uniform. Traffic of autoreactive T cells into the pancreas is likely to contribute to insulitis progression but it could also depend on T-cell proliferation within islets. This study utilizes transgenic NOD mice to assess the relative contributions of these two mechanisms.
Original languageEnglish
Pages (from-to)1717 - 1722
Number of pages6
JournalEuropean Journal of Immunology
Issue number7
Publication statusPublished - 2012

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