Intra-aortic balloon pump effects on macrocirculation and microcirculation in cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation

Thibaut Petroni, Anatole Harrois, Julien Amour, Guillaume Lebreton, Nicolas Brechot, Sébastien Tanaka, Charles-Edouard Luyt, Jean-Louis Trouillet, Jean Chastre, Pascal Leprince, Jacques Duranteau, Alain Combes

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Abstract

This study was designed to assess the effects on macrocirculation and microcirculation of adding an intra-aortic balloon pump to peripheral venoarterial extracorporeal membrane oxygenation in patients with severe cardiogenic shock and little/no residual left ventricular ejection. Design: A prospective, single-center, observational study where macrocirculation and microcirculation were assessed with clinical-, Doppler echocardiography-, and pulmonary artery-derived hemodynamic variables and also cerebral and thenar eminence tissue oxygenation and side-stream dark-field imaging of sublingual microcirculation. Setting: A 26-bed tertiary ICU in a university hospital. Patients: We evaluated 12 consecutive patients before and 30 minutes after interrupting and restarting intra-aortic balloon pump. Interventions: Measurements were performed before, and 30 minutes after interrupting and restarting intra-aortic balloon pump. Measurements and Main Results: Stopping intra-aortic balloon pump was associated with higher pulmonary artery-occlusion pressure (19 ± 10 vs 15 ± 8 mm Hg, p = 0.01), increased left ventricular end-systolic (51 ± 13 vs 50 ± 14 mm, p = 0.05) and end-diastolic (55 ± 13 vs 52 ± 14 mm, p = 0.003) dimensions, and decreased pulse pressure (15 ± 13 vs 29 ± 22 mm Hg, p = 0.02). Maximum pulmonary artery-occlusion pressure reduction when the intra-aortic balloon pump was restarted was observed in the seven patients whose pulmonary artery-occlusion pressure was more than 15 mm Hg when intra-aortic balloon pump was off (-6.6 ± 4.3 vs-0.6 ± 3.4 mm Hg, respectively). Thenar eminence and brain tissue oxygenation and side-stream dark-field-assessed sublingual microcirculation were unchanged by stopping and restarting intra-aortic balloon pump. Conclusions: Restoring pulsatility and decreasing left ventricular afterload with intra-aortic balloon pump was associated with smaller left ventricular dimensions and lower pulmonary artery pressures but did not affect microcirculation variables in cardiogenic shock patients with little/no residual left ventricular ejection while on peripheral venoarterial extracorporeal membrane oxygenation.

Original languageEnglish
Pages (from-to)2075-2082
Number of pages8
JournalCritical Care Medicine
Volume42
Issue number9
DOIs
Publication statusPublished - Sep 2014
Externally publishedYes

Keywords

  • cardiogenic shock
  • extracorporeal membrane oxygenation
  • macrocirculation
  • microcirculation
  • pulmonary edema

Cite this

Petroni, T., Harrois, A., Amour, J., Lebreton, G., Brechot, N., Tanaka, S., Luyt, C-E., Trouillet, J-L., Chastre, J., Leprince, P., Duranteau, J., & Combes, A. (2014). Intra-aortic balloon pump effects on macrocirculation and microcirculation in cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation. Critical Care Medicine, 42(9), 2075-2082. https://doi.org/10.1097/CCM.0000000000000410