Intra- and interhost genomic diversity of monkeypox virus

Mona L. Taouk; Eike Steinig; George Taiaroa; Ivana Savic; Thomas Tran; Nasra Higgins; Stephanie Tran; Alvin Lee; Maxwell Braddick; Michael A. Moso; Eric P.F. Chow; Christopher K. Fairley; Janet Towns; Marcus Y. Chen; Leon Caly; Chuan K. Lim; Deborah A. Williamson

doi:10.1002/jmv.29029

Intra- and interhost genomic diversity of monkeypox virus

Mona L. Taouk, Eike Steinig, George Taiaroa, Ivana Savic, Thomas Tran, Nasra Higgins, Stephanie Tran, Alvin Lee, Maxwell Braddick, Michael A. Moso, Eric P.F. Chow, Christopher K. Fairley, Janet Towns, Marcus Y. Chen, Leon Caly, Chuan K. Lim, Deborah A. Williamson

Melbourne Sexual Health Centre

Research output: Contribution to journal › Article › Research › peer-review

11 Citations (Scopus)

Abstract

The impact and frequency of infectious disease outbreaks demonstrate the need for timely genomic surveillance to inform public health responses. In the largest known outbreak of mpox, genomic surveillance efforts have primarily focused on high-incidence nations in Europe and the Americas, with a paucity of data from South-East Asia and the Western Pacific. Here we analyzed 102 monkeypox virus (MPXV) genomes sampled from 56 individuals in Melbourne, Australia. All genomes fell within the 2022 MPXV outbreak lineage (B.1), with likely onward local transmission detected. We observed within-host diversity and instances of co-infection, and highlight further examples of structural variation and apolipoprotein B editing complex-driven micro-evolution in the current MPXV outbreak. Updating our understanding of MPXV emergence and diversification will inform public health measures and enable monitoring of the virus’ evolutionary trajectory throughout the mpox outbreak.

Original language	English
Article number	e29029
Number of pages	12
Journal	Journal of Medical Virology
Volume	95
Issue number	8
DOIs	https://doi.org/10.1002/jmv.29029
Publication status	Published - Aug 2023

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

monkeypox virus
mpox
whole genome sequencing

Access to Document

10.1002/jmv.29029Licence: CC BY

Cite this

Taouk, M. L., Steinig, E., Taiaroa, G., Savic, I., Tran, T., Higgins, N., Tran, S., Lee, A., Braddick, M., Moso, M. A., Chow, E. P. F., Fairley, C. K., Towns, J., Chen, M. Y., Caly, L., Lim, C. K., & Williamson, D. A. (2023). Intra- and interhost genomic diversity of monkeypox virus. Journal of Medical Virology, 95(8), Article e29029. https://doi.org/10.1002/jmv.29029

@article{000fcf7afda8447d8ebb98d4ec7d9c4b,

title = "Intra- and interhost genomic diversity of monkeypox virus",

abstract = "The impact and frequency of infectious disease outbreaks demonstrate the need for timely genomic surveillance to inform public health responses. In the largest known outbreak of mpox, genomic surveillance efforts have primarily focused on high-incidence nations in Europe and the Americas, with a paucity of data from South-East Asia and the Western Pacific. Here we analyzed 102 monkeypox virus (MPXV) genomes sampled from 56 individuals in Melbourne, Australia. All genomes fell within the 2022 MPXV outbreak lineage (B.1), with likely onward local transmission detected. We observed within-host diversity and instances of co-infection, and highlight further examples of structural variation and apolipoprotein B editing complex-driven micro-evolution in the current MPXV outbreak. Updating our understanding of MPXV emergence and diversification will inform public health measures and enable monitoring of the virus{\textquoteright} evolutionary trajectory throughout the mpox outbreak.",

keywords = "monkeypox virus, mpox, whole genome sequencing",

author = "Taouk, \{Mona L.\} and Eike Steinig and George Taiaroa and Ivana Savic and Thomas Tran and Nasra Higgins and Stephanie Tran and Alvin Lee and Maxwell Braddick and Moso, \{Michael A.\} and Chow, \{Eric P.F.\} and Fairley, \{Christopher K.\} and Janet Towns and Chen, \{Marcus Y.\} and Leon Caly and Lim, \{Chuan K.\} and Williamson, \{Deborah A.\}",

note = "Funding Information: Mona L. Taouk is supported by an Australian Government Research Training Program Scholarship. Deborah A. Williamson is supported by a National Health and Medical Research Council (NHMRC) Investigator Grant (APP1174555) and a Medical Research Future Fund (MRFF) Grant (FSPGN000045). Christopher K. Fairly is supported by an NHMRC Investigator Grant (APP1172900). Eric P. F. Chow is supported by an NHMRC Investigator Grant (GNT1172873). Janet Towns is supported by an NHMRC Partner Project Grant (APP2003399). Open access publishing facilitated by The University of Melbourne, as part of the Wiley ‐ The University of Melbourne agreement via the Council of Australian University Librarians. Funding Information: Mona L. Taouk is supported by an Australian Government Research Training Program Scholarship. Deborah A. Williamson is supported by a National Health and Medical Research Council (NHMRC) Investigator Grant (APP1174555) and a Medical Research Future Fund (MRFF) Grant (FSPGN000045). Christopher K. Fairly is supported by an NHMRC Investigator Grant (APP1172900). Eric P. F. Chow is supported by an NHMRC Investigator Grant (GNT1172873). Janet Towns is supported by an NHMRC Partner Project Grant (APP2003399). Open access publishing facilitated by The University of Melbourne, as part of the Wiley - The University of Melbourne agreement via the Council of Australian University Librarians. Publisher Copyright: {\textcopyright} 2023 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.",

year = "2023",

month = aug,

doi = "10.1002/jmv.29029",

language = "English",

volume = "95",

journal = "Journal of Medical Virology",

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publisher = "John Wiley \& Sons",

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AU - Steinig, Eike

AU - Taiaroa, George

AU - Savic, Ivana

AU - Tran, Thomas

AU - Higgins, Nasra

AU - Tran, Stephanie

AU - Lee, Alvin

AU - Braddick, Maxwell

AU - Moso, Michael A.

AU - Chow, Eric P.F.

AU - Fairley, Christopher K.

AU - Towns, Janet

AU - Chen, Marcus Y.

AU - Caly, Leon

AU - Lim, Chuan K.

AU - Williamson, Deborah A.

N1 - Funding Information: Mona L. Taouk is supported by an Australian Government Research Training Program Scholarship. Deborah A. Williamson is supported by a National Health and Medical Research Council (NHMRC) Investigator Grant (APP1174555) and a Medical Research Future Fund (MRFF) Grant (FSPGN000045). Christopher K. Fairly is supported by an NHMRC Investigator Grant (APP1172900). Eric P. F. Chow is supported by an NHMRC Investigator Grant (GNT1172873). Janet Towns is supported by an NHMRC Partner Project Grant (APP2003399). Open access publishing facilitated by The University of Melbourne, as part of the Wiley ‐ The University of Melbourne agreement via the Council of Australian University Librarians. Funding Information: Mona L. Taouk is supported by an Australian Government Research Training Program Scholarship. Deborah A. Williamson is supported by a National Health and Medical Research Council (NHMRC) Investigator Grant (APP1174555) and a Medical Research Future Fund (MRFF) Grant (FSPGN000045). Christopher K. Fairly is supported by an NHMRC Investigator Grant (APP1172900). Eric P. F. Chow is supported by an NHMRC Investigator Grant (GNT1172873). Janet Towns is supported by an NHMRC Partner Project Grant (APP2003399). Open access publishing facilitated by The University of Melbourne, as part of the Wiley - The University of Melbourne agreement via the Council of Australian University Librarians. Publisher Copyright: © 2023 The Authors. Journal of Medical Virology published by Wiley Periodicals LLC.

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N2 - The impact and frequency of infectious disease outbreaks demonstrate the need for timely genomic surveillance to inform public health responses. In the largest known outbreak of mpox, genomic surveillance efforts have primarily focused on high-incidence nations in Europe and the Americas, with a paucity of data from South-East Asia and the Western Pacific. Here we analyzed 102 monkeypox virus (MPXV) genomes sampled from 56 individuals in Melbourne, Australia. All genomes fell within the 2022 MPXV outbreak lineage (B.1), with likely onward local transmission detected. We observed within-host diversity and instances of co-infection, and highlight further examples of structural variation and apolipoprotein B editing complex-driven micro-evolution in the current MPXV outbreak. Updating our understanding of MPXV emergence and diversification will inform public health measures and enable monitoring of the virus’ evolutionary trajectory throughout the mpox outbreak.

AB - The impact and frequency of infectious disease outbreaks demonstrate the need for timely genomic surveillance to inform public health responses. In the largest known outbreak of mpox, genomic surveillance efforts have primarily focused on high-incidence nations in Europe and the Americas, with a paucity of data from South-East Asia and the Western Pacific. Here we analyzed 102 monkeypox virus (MPXV) genomes sampled from 56 individuals in Melbourne, Australia. All genomes fell within the 2022 MPXV outbreak lineage (B.1), with likely onward local transmission detected. We observed within-host diversity and instances of co-infection, and highlight further examples of structural variation and apolipoprotein B editing complex-driven micro-evolution in the current MPXV outbreak. Updating our understanding of MPXV emergence and diversification will inform public health measures and enable monitoring of the virus’ evolutionary trajectory throughout the mpox outbreak.

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KW - mpox

KW - whole genome sequencing

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SN - 0146-6615

VL - 95

JO - Journal of Medical Virology

JF - Journal of Medical Virology

IS - 8

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ER -

Intra- and interhost genomic diversity of monkeypox virus

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Optimising the control and management of sexually transmitted infections through research and innovation

A multidisciplinary approach to understanding the transmission dynamics and the control of sexually transmitted infections

Cite this

Intra- and interhost genomic diversity of monkeypox virus

Abstract

UN SDGs

Keywords

Access to Document

Other files and links

Projects

Optimising the control and management of sexually transmitted infections through research and innovation

A multidisciplinary approach to understanding the transmission dynamics and the control of sexually transmitted infections

Cite this