Intra-amniotic corticosteroids for preterm lung maturation in sheep

Timothy Moss, Neil Mulrooney, Ilias Nitsos, Machiko Ikegami, Alan Jobe, John Newnham

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Abstract

OBJECTIVE: The purpose of this study was to compare efficacy on fetal lung maturation of intra-amniotic betamethasone or budesonide with the efficacy of maternal intramuscular betamethasone. STUDY DESIGN: Pregnant ewes received intra-amniotic betamethasone (0.5 mg/kg or 2 mg/kg fetal weight), intra-amniotic budesonide (0.5 mg/kg or 2 mg/kg), maternal intramuscular betamethasone (0.5 mg/kg maternal weight), intra-amniotic saline solution, or maternal saline solution. Lambs were delivered 2 or 7 days later, at 124 days of gestation for measurement of respiratory system compliance, ventilatory efficiency index, and surfactant levels. RESULTS: Lung function increased 2 days after maternal betamethasone, intra-amniotic betamethasone (2 mg/kg), and intra-amniotic budesonide (2 mg/kg) administration and 7 days after maternal betamethasone or intra-amniotic budesonide (2.0 mg/kg) administration. Lung function was not improved 7 days after intra-amniotic betamethasone (2.0 mg/kg) administration or 2 days after intra-amniotic betamethasone (0.5 mg/kg) or intra-amniotic budesonide (0.5 mg/kg) administration. Intra-amniotic corticosteroid administration increased fetal death and respiratory morbidity. CONCLUSION: Intra-amniotic corticosteroid administration improved preterm lung function, but the associated morbidity and mortality rates suggest that they are not suitable for clinical use.
Original languageEnglish
Pages (from-to)1389 - 1395
Number of pages7
JournalAmerican Journal of Obstetrics and Gynecology
Volume189
Issue number5
Publication statusPublished - 2003
Externally publishedYes

Cite this

Moss, T., Mulrooney, N., Nitsos, I., Ikegami, M., Jobe, A., & Newnham, J. (2003). Intra-amniotic corticosteroids for preterm lung maturation in sheep. American Journal of Obstetrics and Gynecology, 189(5), 1389 - 1395.