Intimin and the host cell - Is it bound to end in Tir(s)?

Gad Frankel, Alan D. Phillips, Luiz R. Trabulsi, Stuart Knutton, Gordon Dougan, Stephen Matthews

Research output: Contribution to journalReview ArticleResearchpeer-review

Abstract

Intimate bacterial adhesion to the intestinal epithelium is a pathogenic mechanism shared by several human and animal enteric pathogens, including enteropathogenic and enterohaemorrhagic Escherichia coli. Two bacterial protein partners involved in this intimate association have been identified, intimin and Tir. Some key remaining questions include whether intimin specifically interacts with one or more host-cell-encoded molecules and whether these contacts are a prerequisite for the subsequent intimate intimin-Tir association. Recent data support the hypothesis that the formation of a stable intimin-Tir relationship is the consequence of intimin protein interactions involving both host and bacterial components.

Original languageEnglish
Pages (from-to)214-218
Number of pages5
JournalTrends in Microbiology
Volume9
Issue number5
DOIs
Publication statusPublished - 1 May 2001
Externally publishedYes

Cite this

Frankel, G., Phillips, A. D., Trabulsi, L. R., Knutton, S., Dougan, G., & Matthews, S. (2001). Intimin and the host cell - Is it bound to end in Tir(s)? Trends in Microbiology, 9(5), 214-218. https://doi.org/10.1016/S0966-842X(01)02016-9
Frankel, Gad ; Phillips, Alan D. ; Trabulsi, Luiz R. ; Knutton, Stuart ; Dougan, Gordon ; Matthews, Stephen. / Intimin and the host cell - Is it bound to end in Tir(s)?. In: Trends in Microbiology. 2001 ; Vol. 9, No. 5. pp. 214-218.
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Frankel, G, Phillips, AD, Trabulsi, LR, Knutton, S, Dougan, G & Matthews, S 2001, 'Intimin and the host cell - Is it bound to end in Tir(s)?', Trends in Microbiology, vol. 9, no. 5, pp. 214-218. https://doi.org/10.1016/S0966-842X(01)02016-9

Intimin and the host cell - Is it bound to end in Tir(s)? / Frankel, Gad; Phillips, Alan D.; Trabulsi, Luiz R.; Knutton, Stuart; Dougan, Gordon; Matthews, Stephen.

In: Trends in Microbiology, Vol. 9, No. 5, 01.05.2001, p. 214-218.

Research output: Contribution to journalReview ArticleResearchpeer-review

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