Intestinal Stem Cell Dynamics: A Story of Mice and Humans

Michael C. Hodder, Dustin J. Flanagan, Owen J. Sansom

Research output: Contribution to journalEditorialOtherpeer-review

4 Citations (Scopus)

Abstract

Stem cell dynamics define the probability of accumulating mutations within the intestinal epithelium. In this issue of Cell Stem Cell, Nicholson et al. (2018) report that human intestinal stem cell dynamics differ significantly from those of mice and establish that oncogenic mutations are more likely to expand; therefore, “normal” epithelium may carry multiple mutations. Stem cell dynamics define the probability of accumulating mutations within the intestinal epithelium. In this issue of Cell Stem Cell, Nicholson et al. (2018) report that human intestinal stem cell dynamics differ significantly from those of mice and establish that oncogenic mutations are more likely to expand; therefore, “normal” epithelium may carry multiple mutations.

Original languageEnglish
Pages (from-to)785-787
Number of pages3
JournalCell Stem Cell
Volume22
Issue number6
DOIs
Publication statusPublished - 1 Jun 2018
Externally publishedYes

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