Intestinal stem cell aging signature reveals a reprogramming strategy to enhance regenerative potential

Christian M. Nefzger, Thierry Jardé, Akanksha Srivastava, Jan Schroeder, Fernando J. Rossello, Katja Horvay, Mirsada Prasko, Jacob M. Paynter, Joseph Chen, Chen Fang Weng, Yu B.Y. Sun, Xiaodong Liu, Eva Chan, Nikita Deshpande, Xiaoli Chen, Y. Jinhua Li, Jahnvi Pflueger, Rebekah M. Engel, Anja S. Knaupp, Kirill TsyganovSusan K. Nilsson, Ryan Lister, Owen J.L. Rackham, Helen E. Abud, Jose M. Polo

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Abstract

The impact of aging on intestinal stem cells (ISCs) has not been fully elucidated. In this study, we identified widespread epigenetic and transcriptional alterations in old ISCs. Using a reprogramming algorithm, we identified a set of key transcription factors (Egr1, Irf1, FosB) that drives molecular and functional differences between old and young states. Overall, by dissecting the molecular signature of aged ISCs, our study identified transcription factors that enhance the regenerative capacity of ISCs.

Original languageEnglish
Article number31
Number of pages8
Journalnpj Regenerative Medicine
Volume7
Issue number1
DOIs
Publication statusPublished - Dec 2022

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