Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism

Natalie Trevaskis; David Shackleford; William Neil Charman; Glenn A Edwards; Anne Gardin; Silke Appel-Dingemanse; Oliver Kretz; Bruno Galli; Christopher John Porter

doi:10.1007/s11095-009-9860-z

Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism

Natalie Trevaskis
, David Shackleford
, William Neil Charman
, Glenn A Edwards
, Anne Gardin
, Silke Appel-Dingemanse
, Oliver Kretz
, Bruno Galli
, Christopher John Porter

Research output: Contribution to journal › Article › Research › peer-review

50 Citations (Scopus)

Abstract

To examine the effect of food on the oral bioavailability of a highly lipophilic, cannabinoid receptor agonist (CRA13) and to explore the basis for the food effect in lymph-cannulated and non-cannulated dogs.

Original language	English
Pages (from-to)	1486 - 1495
Number of pages	10
Journal	Pharmaceutical Research
Volume	26
Issue number	6
DOIs	https://doi.org/10.1007/s11095-009-9860-z
Publication status	Published - 2009

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10.1007/s11095-009-9860-z

Cite this

Trevaskis, N., Shackleford, D., Charman, W. N., Edwards, G. A., Gardin, A., Appel-Dingemanse, S., Kretz, O., Galli, B., & Porter, C. J. (2009). Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism. Pharmaceutical Research, 26(6), 1486 - 1495. https://doi.org/10.1007/s11095-009-9860-z

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title = "Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism",

abstract = "To examine the effect of food on the oral bioavailability of a highly lipophilic, cannabinoid receptor agonist (CRA13) and to explore the basis for the food effect in lymph-cannulated and non-cannulated dogs.",

author = "Natalie Trevaskis and David Shackleford and Charman, \{William Neil\} and Edwards, \{Glenn A\} and Anne Gardin and Silke Appel-Dingemanse and Oliver Kretz and Bruno Galli and Porter, \{Christopher John\}",

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doi = "10.1007/s11095-009-9860-z",

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Trevaskis, N , Shackleford, D, Charman, WN, Edwards, GA, Gardin, A, Appel-Dingemanse, S, Kretz, O, Galli, B & Porter, CJ 2009, 'Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism', Pharmaceutical Research, vol. 26, no. 6, pp. 1486 - 1495. https://doi.org/10.1007/s11095-009-9860-z

Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism. / Trevaskis, Natalie ; Shackleford, David; Charman, William Neil et al.
In: Pharmaceutical Research, Vol. 26, No. 6, 2009, p. 1486 - 1495.

Research output: Contribution to journal › Article › Research › peer-review

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AU - Trevaskis, Natalie

AU - Shackleford, David

AU - Charman, William Neil

AU - Edwards, Glenn A

AU - Gardin, Anne

AU - Appel-Dingemanse, Silke

AU - Kretz, Oliver

AU - Galli, Bruno

AU - Porter, Christopher John

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DO - 10.1007/s11095-009-9860-z

M3 - Article

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VL - 26

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JO - Pharmaceutical Research

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