Intestinal lymphatic transport enhances the post-prandial oral bioavailability of a novel cannabinoid receptor agonist via avoidance of first-pass metabolism

Natalie Trevaskis, David Shackleford, William Neil Charman, Glenn A Edwards, Anne Gardin, Silke Appel-Dingemanse, Oliver Kretz, Bruno Galli, Christopher John Porter

Research output: Contribution to journalArticleResearchpeer-review

38 Citations (Scopus)

Abstract

To examine the effect of food on the oral bioavailability of a highly lipophilic, cannabinoid receptor agonist (CRA13) and to explore the basis for the food effect in lymph-cannulated and non-cannulated dogs.
Original languageEnglish
Pages (from-to)1486 - 1495
Number of pages10
JournalPharmaceutical Research
Volume26
Issue number6
DOIs
Publication statusPublished - 2009

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