Intestinal lymphatic dysfunction: a new pathway mediating gut–kidney crosstalk in kidney disease

Research output: Contribution to journalComment / DebateOtherpeer-review

2 Citations (Scopus)


The importance of kidney-gut crosstalk in driving kidney disease complications is increasingly being realized. However, little attention has been given to intestinal lymphatic changes in kidney disease. Zhong et al. report striking changes to intestinal lymphatic composition, structure, and function in proteinuric kidney injury models, including increased lymphangiogenesis, lymph flow, and transport of lipoproteins and proinflammatory mediators. These changes appear to be stimulated by isolevuglandin (IsoLG)-modified apolipoprotein AI (ApoAI). This intestinal lymphatic response may regulate systemic complications.

Original languageEnglish
Pages (from-to)511-513
Number of pages3
JournalKidney International
Issue number3
Publication statusPublished - 1 Sept 2021

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