TY - JOUR
T1 - Intestinal lymphatic dysfunction
T2 - a new pathway mediating gut–kidney crosstalk in kidney disease
AU - Trevaskis, Natalie L.
N1 - Publisher Copyright:
© 2021
Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 2021/9/1
Y1 - 2021/9/1
N2 - The importance of kidney-gut crosstalk in driving kidney disease complications is increasingly being realized. However, little attention has been given to intestinal lymphatic changes in kidney disease. Zhong et al. report striking changes to intestinal lymphatic composition, structure, and function in proteinuric kidney injury models, including increased lymphangiogenesis, lymph flow, and transport of lipoproteins and proinflammatory mediators. These changes appear to be stimulated by isolevuglandin (IsoLG)-modified apolipoprotein AI (ApoAI). This intestinal lymphatic response may regulate systemic complications.
AB - The importance of kidney-gut crosstalk in driving kidney disease complications is increasingly being realized. However, little attention has been given to intestinal lymphatic changes in kidney disease. Zhong et al. report striking changes to intestinal lymphatic composition, structure, and function in proteinuric kidney injury models, including increased lymphangiogenesis, lymph flow, and transport of lipoproteins and proinflammatory mediators. These changes appear to be stimulated by isolevuglandin (IsoLG)-modified apolipoprotein AI (ApoAI). This intestinal lymphatic response may regulate systemic complications.
UR - http://www.scopus.com/inward/record.url?scp=85112420171&partnerID=8YFLogxK
U2 - 10.1016/j.kint.2021.06.022
DO - 10.1016/j.kint.2021.06.022
M3 - Editorial
AN - SCOPUS:85112420171
SN - 0085-2538
VL - 100
SP - 511
EP - 513
JO - Kidney International
JF - Kidney International
IS - 3
ER -