Intestinal bacteria induce TSLP to promote mutualistic T-cell responses

I. Mosconi, M. B. Geuking, M. M. Zaiss, J. C. Massacand, C. Aschwanden, C. K.C. Kwong Chung, K. D. Mccoy, N. L. Harris

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Thymic stromal lymphopoietin (TSLP) is constitutively expressed in the intestine and is known to regulate inflammation in models of colitis. We show that steady-state TSLP expression requires intestinal bacteria and has an important role in limiting the expansion of colonic T helper type 17 (Th17) cells. Inappropriate expansion of the colonic Th17 cells occurred in response to an entirely benign intestinal microbiota, as determined following the colonization of germ-free C57BL/6 or TSLPR -/- mice with the altered Schaedler flora (ASF). TSLP-TSLPR (TSLP receptor) interactions also promoted the expansion of colonic Helios - Foxp3 + regulatory T cells, necessary for the control of inappropriate Th17 responses following ASF bacterial colonization. In summary, these data reveal an important role for TSLP-TSLPR signaling in promoting steady-state mutualistic T-cell responses following intestinal bacterial colonization.

Original languageEnglish
Pages (from-to)1157-1167
Number of pages11
JournalMucosal Immunology
Issue number6
Publication statusPublished - 1 Nov 2013
Externally publishedYes

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