Interplay between influenza A virus and host factors: Targets for antiviral intervention

Shashank Tripathi, Jyoti Batra, Sunil Kumar Lal

    Research output: Contribution to journalReview ArticleResearchpeer-review

    14 Citations (Scopus)

    Abstract

    Influenza A viruses (IAVs) pose a major public health threat worldwide. Recent experience with the 2013 H7N9 outbreak in China and the 2009 ?swine flu? pandemic have shown that antiviral vaccines and drugs fall short of controlling the spread of disease in a timely and effective manner. Major problems include rapid emergence of drug-resistant influenza virus strains and the slow process of vaccine production. With the threat of a highly pathogenic H5N1 bird-flu pandemic looming large, it is crucial to develop novel ways of combating influenza A viruses. Targeting the host factors critical for influenza A virus replication has shown promise as a strategy to develop novel antiviral molecules with broad-spectrum protection. In this review, we summarize the role of currently identified host factors that play a critical role in the influenza A virus life cycle and discuss the most promising candidates for anti-influenza therapeutics
    Original languageEnglish
    Pages (from-to)1877-1891
    Number of pages15
    JournalArchives of Virology
    Volume160
    Issue number8
    DOIs
    Publication statusPublished - 2015

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