Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Ailin Lepletier, Michael L. Hun, Maree V. Hammett, Kahlia Wong, Haroon Naeem, Mark Hedger, Kate Loveland, Ann P. Chidgey

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13 Citations (Scopus)


Mechanisms underlying age-associated thymic involution remain elusive. Here, Lepletier et al. show that an imbalance in activin A and BMP4 signaling drives thymic involution. This occurs in two major stages: impairment of medullary TEC differentiation and initiation of TEPC quiescence, followed by the broader, negative impact of reduced lineage committed precursors.

Original languageEnglish
Pages (from-to)3887–3901–e4
Number of pages19
JournalCell Reports
Issue number13
Publication statusPublished - 25 Jun 2019


  • activin A
  • androgen blockade
  • BMP4
  • follistatin
  • immune aging
  • thymic epithelial cells
  • thymic epithelial progenitor
  • thymic involution
  • thymus
  • thymus regeneration

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