Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Ailin Lepletier; Michael L. Hun; Maree V. Hammett; Kahlia Wong; Haroon Naeem; Mark Hedger; Kate Loveland; Ann P. Chidgey

doi:10.1016/j.celrep.2019.05.045

Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Ailin Lepletier, Michael L. Hun, Maree V. Hammett, Kahlia Wong, Haroon Naeem, Mark Hedger, Kate Loveland, Ann P. Chidgey

Research output: Contribution to journal › Article › Research › peer-review

42 Citations (Scopus)

Abstract

Mechanisms underlying age-associated thymic involution remain elusive. Here, Lepletier et al. show that an imbalance in activin A and BMP4 signaling drives thymic involution. This occurs in two major stages: impairment of medullary TEC differentiation and initiation of TEPC quiescence, followed by the broader, negative impact of reduced lineage committed precursors.

Original language	English
Pages (from-to)	3887–3901–e4
Number of pages	19
Journal	Cell Reports
Volume	27
Issue number	13
DOIs	https://doi.org/10.1016/j.celrep.2019.05.045
Publication status	Published - 25 Jun 2019

Keywords

activin A
androgen blockade
BMP4
follistatin
immune aging
thymic epithelial cells
thymic epithelial progenitor
thymic involution
thymus
thymus regeneration

Access to Document

10.1016/j.celrep.2019.05.045Licence: CC BY-NC-ND

277594545-oaFinal published version, 5.73 MBLicence: CC BY-NC-ND

Cite this

@article{e5be27f6a1d649c3b180b4f898cc87d1,

title = "Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging",

abstract = "Mechanisms underlying age-associated thymic involution remain elusive. Here, Lepletier et al. show that an imbalance in activin A and BMP4 signaling drives thymic involution. This occurs in two major stages: impairment of medullary TEC differentiation and initiation of TEPC quiescence, followed by the broader, negative impact of reduced lineage committed precursors.",

keywords = "activin A, androgen blockade, BMP4, follistatin, immune aging, thymic epithelial cells, thymic epithelial progenitor, thymic involution, thymus, thymus regeneration",

author = "Ailin Lepletier and Hun, {Michael L.} and Hammett, {Maree V.} and Kahlia Wong and Haroon Naeem and Mark Hedger and Kate Loveland and Chidgey, {Ann P.}",

year = "2019",

month = jun,

day = "25",

doi = "10.1016/j.celrep.2019.05.045",

language = "English",

volume = "27",

pages = "3887–3901–e4",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Elsevier",

number = "13",

}

TY - JOUR

T1 - Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

AU - Lepletier, Ailin

AU - Hun, Michael L.

AU - Hammett, Maree V.

AU - Wong, Kahlia

AU - Naeem, Haroon

AU - Hedger, Mark

AU - Loveland, Kate

AU - Chidgey, Ann P.

PY - 2019/6/25

Y1 - 2019/6/25

N2 - Mechanisms underlying age-associated thymic involution remain elusive. Here, Lepletier et al. show that an imbalance in activin A and BMP4 signaling drives thymic involution. This occurs in two major stages: impairment of medullary TEC differentiation and initiation of TEPC quiescence, followed by the broader, negative impact of reduced lineage committed precursors.

AB - Mechanisms underlying age-associated thymic involution remain elusive. Here, Lepletier et al. show that an imbalance in activin A and BMP4 signaling drives thymic involution. This occurs in two major stages: impairment of medullary TEC differentiation and initiation of TEPC quiescence, followed by the broader, negative impact of reduced lineage committed precursors.

KW - activin A

KW - androgen blockade

KW - BMP4

KW - follistatin

KW - immune aging

KW - thymic epithelial cells

KW - thymic epithelial progenitor

KW - thymic involution

KW - thymus

KW - thymus regeneration

UR - http://www.scopus.com/inward/record.url?scp=85067195331&partnerID=8YFLogxK

U2 - 10.1016/j.celrep.2019.05.045

DO - 10.1016/j.celrep.2019.05.045

M3 - Article

AN - SCOPUS:85067195331

SN - 2211-1247

VL - 27

SP - 3887–3901–e4

JO - Cell Reports

JF - Cell Reports

IS - 13

ER -

Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Abstract

Keywords

Access to Document

Other files and links

Stem cell based strategies for re-establishing T cell immunity in aging and disease.

Bioinformatics Platform

FlowCore

Histology Platform

Cite this

Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Abstract

Keywords

Access to Document

Other files and links

Projects

Stem cell based strategies for re-establishing T cell immunity in aging and disease.

Equipment

Bioinformatics Platform

FlowCore

Histology Platform

Cite this