Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Ailin Lepletier, Michael L. Hun, Maree V. Hammett, Kahlia Wong, Haroon Naeem, Mark Hedger, Kate Loveland, Ann P. Chidgey

Research output: Contribution to journalArticleResearchpeer-review

3 Citations (Scopus)

Abstract

Mechanisms underlying age-associated thymic involution remain elusive. Here, Lepletier et al. show that an imbalance in activin A and BMP4 signaling drives thymic involution. This occurs in two major stages: impairment of medullary TEC differentiation and initiation of TEPC quiescence, followed by the broader, negative impact of reduced lineage committed precursors.

Original languageEnglish
Pages (from-to)3887–3901–e4
Number of pages19
JournalCell Reports
Volume27
Issue number13
DOIs
Publication statusPublished - 25 Jun 2019

Keywords

  • activin A
  • androgen blockade
  • BMP4
  • follistatin
  • immune aging
  • thymic epithelial cells
  • thymic epithelial progenitor
  • thymic involution
  • thymus
  • thymus regeneration

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