Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

Ailin Lepletier, Michael L. Hun, Maree V. Hammett, Kahlia Wong, Haroon Naeem, Mark Hedger, Kate Loveland, Ann P. Chidgey

Research output: Contribution to journalArticleResearchpeer-review

Abstract

Mechanisms underlying age-associated thymic involution remain elusive. Here, Lepletier et al. show that an imbalance in activin A and BMP4 signaling drives thymic involution. This occurs in two major stages: impairment of medullary TEC differentiation and initiation of TEPC quiescence, followed by the broader, negative impact of reduced lineage committed precursors.

Original languageEnglish
Pages (from-to)3887–3901–e4
Number of pages19
JournalCell Reports
Volume27
Issue number13
DOIs
Publication statusPublished - 25 Jun 2019

Keywords

  • activin A
  • androgen blockade
  • BMP4
  • follistatin
  • immune aging
  • thymic epithelial cells
  • thymic epithelial progenitor
  • thymic involution
  • thymus
  • thymus regeneration

Cite this

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title = "Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging",
abstract = "Mechanisms underlying age-associated thymic involution remain elusive. Here, Lepletier et al. show that an imbalance in activin A and BMP4 signaling drives thymic involution. This occurs in two major stages: impairment of medullary TEC differentiation and initiation of TEPC quiescence, followed by the broader, negative impact of reduced lineage committed precursors.",
keywords = "activin A, androgen blockade, BMP4, follistatin, immune aging, thymic epithelial cells, thymic epithelial progenitor, thymic involution, thymus, thymus regeneration",
author = "Ailin Lepletier and Hun, {Michael L.} and Hammett, {Maree V.} and Kahlia Wong and Haroon Naeem and Mark Hedger and Kate Loveland and Chidgey, {Ann P.}",
year = "2019",
month = "6",
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language = "English",
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publisher = "Elsevier",
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Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging. / Lepletier, Ailin; Hun, Michael L.; Hammett, Maree V.; Wong, Kahlia; Naeem, Haroon; Hedger, Mark; Loveland, Kate; Chidgey, Ann P.

In: Cell Reports, Vol. 27, No. 13, 25.06.2019, p. 3887–3901–e4.

Research output: Contribution to journalArticleResearchpeer-review

TY - JOUR

T1 - Interplay between Follistatin, Activin A, and BMP4 Signaling Regulates Postnatal Thymic Epithelial Progenitor Cell Differentiation during Aging

AU - Lepletier, Ailin

AU - Hun, Michael L.

AU - Hammett, Maree V.

AU - Wong, Kahlia

AU - Naeem, Haroon

AU - Hedger, Mark

AU - Loveland, Kate

AU - Chidgey, Ann P.

PY - 2019/6/25

Y1 - 2019/6/25

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AB - Mechanisms underlying age-associated thymic involution remain elusive. Here, Lepletier et al. show that an imbalance in activin A and BMP4 signaling drives thymic involution. This occurs in two major stages: impairment of medullary TEC differentiation and initiation of TEPC quiescence, followed by the broader, negative impact of reduced lineage committed precursors.

KW - activin A

KW - androgen blockade

KW - BMP4

KW - follistatin

KW - immune aging

KW - thymic epithelial cells

KW - thymic epithelial progenitor

KW - thymic involution

KW - thymus

KW - thymus regeneration

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VL - 27

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JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

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