Projects per year
Abstract
Mechanisms underlying age-associated thymic involution remain elusive. Here, Lepletier et al. show that an imbalance in activin A and BMP4 signaling drives thymic involution. This occurs in two major stages: impairment of medullary TEC differentiation and initiation of TEPC quiescence, followed by the broader, negative impact of reduced lineage committed precursors.
Original language | English |
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Pages (from-to) | 3887–3901–e4 |
Number of pages | 19 |
Journal | Cell Reports |
Volume | 27 |
Issue number | 13 |
DOIs | |
Publication status | Published - 25 Jun 2019 |
Keywords
- activin A
- androgen blockade
- BMP4
- follistatin
- immune aging
- thymic epithelial cells
- thymic epithelial progenitor
- thymic involution
- thymus
- thymus regeneration
Projects
- 1 Finished
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Stem cell based strategies for re-establishing T cell immunity in aging and disease.
Chidgey, A., Stanley, E. & Forsythe, J.
National Health and Medical Research Council (NHMRC) (Australia)
1/01/17 → 31/12/19
Project: Research
Equipment
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Bioinformatics Platform
Deanna Deveson (Manager)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility
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FlowCore
Andrew Fryga (Manager)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility
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Histology Platform
Camilla Cohen (Manager)
Faculty of Medicine Nursing and Health Sciences Research PlatformsFacility/equipment: Facility